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World J Crit Care Med. Jun 9, 2025; 14(2): 98791
Published online Jun 9, 2025. doi: 10.5492/wjccm.v14.i2.98791
Why should lymphocytes immune profile matter in sepsis?
Wagner Nedel, Lílian R Henrique, Luis Valmor Portela
Wagner Nedel, Lílian R Henrique, Department of Intensive Care Unit, Conceição Hospital Group, Porto Alegre 91350200, Brazil
Luis Valmor Portela, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil
Author contributions: Nedel W, Henrique LR, and Portela LV reviewed the literature and wrote the manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wagner Nedel, MD, PhD, Assistant Professor, Department of Intensive Care Unit, Conceição Hospital Group, Francisco Trein 596, Segundo Andar, Porto Alegre 91350200, Brazil. wagnernedel@gmail.com
Received: July 5, 2024
Revised: December 11, 2024
Accepted: December 19, 2024
Published online: June 9, 2025
Processing time: 236 Days and 19.2 Hours
Core Tip

Core Tip: Lymphocytes are essential effectors in the immune response to sepsis, contributing to both the initial defense against infection and the regulation of inflammation during the progression to chronic organ failure. One hallmark of sepsis is a profound disruption in lymphocyte homeostasis, that may lead to the development of an immunosuppressive state. Lymphocytes counts and derived variables show significant potential as prognostic markers in sepsis, offering insight into mortality risk and the likelihood of persistent organ dysfunction.