Retrospective Cohort Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Sep 7, 2018; 7(4): 46-51
Published online Sep 7, 2018. doi: 10.5492/wjccm.v7.i4.46
Clinical characteristics and outcomes associated with nasal intermittent mandatory ventilation in acute pediatric respiratory failure
Billy C Wang, Theodore Pei, Cheryl B Lin, Rong Guo, David Elashoff, James A Lin, Carol Pineda
Billy C Wang, Department of Pediatrics, Division of Critical Care Medicine, Loma Linda University Children’s Hospital, Loma Linda, CA 92354, United States
Theodore Pei, Cheryl B Lin, Carol Pineda, Department of Pediatrics, Division of Pediatric Critical Care, Floating Hospital for Children at Tufts, Boston, MA 02111, United States
Rong Guo, David Elashoff, Department of Medicine, Biostatistics Core, UCLA David Geffen School of Medicine, Los Angeles, CA 90024, United States
James A Lin, Department of Pediatrics, Mattel Children’s Hospital at UCLA, Los Angeles, CA 90095, United States
Author contributions: Wang BC, Pei T, Pineda C and Lin JA designed the study, collected data, and participated in writing and revision of the manuscript; Lin CB collected data and reviewed the manuscript; Guo R and Elashoff D provided statistical analysis and reviewed the manuscript
Supported by NIH National Center for Advancing Translational Science, No. UL1TR001881.
Institutional review board statement: This study was approved by the UCLA Institutional Review Board.
Conflict-of-interest statement: All authors have no conflicts of interest to report.
STROBE statement: The STROBE Statement have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Billy C Wang, MD, Fellow, Department of Pediatrics, Division of Critical Care Medicine, Loma Linda University Children’s Hospital, 11234 Anderson Street Room CH5763, Loma Linda, CA 92354, United States. bcwang@llu.edu
Telephone: +1-909-5584250 Fax: +1-909-5580303
Received: June 2, 2018
Peer-review started: June 2, 2018
First decision: July 9, 2018
Revised: July 25, 2018
Accepted: August 4, 2018
Article in press: August 5, 2018
Published online: September 7, 2018
Processing time: 97 Days and 13.6 Hours
Core Tip

Core tip: In our cohort of patients between 0.5 and 28.1 mo of age with acute respiratory failure, the majority of patients were successfully supported with nasal intermittent mandatory ventilation (NIMV) alone or NIMV in conjunction with other modes of noninvasive ventilation (NIV). Use of NIMV with or without NIV was not associated with significant differences in hospital length of stay (LOS), pediatric intensive care unit LOS, or duration of respiratory support. Failure of NIMV with or without NIV was recognized in a median of 6.5 h.