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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Jun 9, 2025; 14(2): 99445
Published online Jun 9, 2025. doi: 10.5492/wjccm.v14.i2.99445
Published online Jun 9, 2025. doi: 10.5492/wjccm.v14.i2.99445
Association between neutrophil-to-lymphocyte ratio and hematoma expansion in spontaneous intracerebral hemorrhage: A systematic review and meta-analysis
Andrea Loggini, Jonatan Hornik, Jessie Henson, Julie Wesler, Alejandro Hornik, Brain and Spine Institute, Southern Illinois Healthcare, Carbondale, IL 62901, United States
Andrea Loggini, Jonatan Hornik, Alejandro Hornik, Southern Illinois University School of Medi
Author contributions: Loggini A was responsible for study concept, study design, data abstraction, data analysis, and drafting the manuscript; Hornik J was responsible for study design, data abstraction, data analysis, and drafting the manuscript; Henson J and Wesler J were responsible for data abstraction and data analysis; Hornik A was responsible for critical revision and approval of the final version of the manuscript; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: None of the authors has any conflict of interest or financial disclosures to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Andrea Loggini, MD, Doctor, Brain and Spine Institute, Southern Illinois Healthcare, 405 W Jackson Street, Carbondale, IL 62901, United States.
Received: July 22, 2024
Revised: December 2, 2024
Accepted: December 16, 2024
Published online: June 9, 2025
Processing time: 219 Days and 12.1 Hours
Revised: December 2, 2024
Accepted: December 16, 2024
Published online: June 9, 2025
Processing time: 219 Days and 12.1 Hours
Core Tip
Core Tip: In this work, we provide an updated and concise quantitative synthesis of the literature addressing the association between neutrophil-to-lymphocyte ratio and hematoma expansion (HE) in intracerebral hemorrhage. We found an independent association between neutrophil-to-lymphocyte ratio (NLR) on admission and HE, and perihematomal growth. Our findings support the idea that NLR could be added as a readily available and inexpensive biomarker to identify a subgroup of patients at higher risk of developing HE.