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World J Crit Care Med. Jun 9, 2025; 14(2): 101777
Published online Jun 9, 2025. doi: 10.5492/wjccm.v14.i2.101777
Post-reperfusion syndrome in liver transplant recipients: What is new in prevention and management?
Austin James Puchany, Ibtesam Hilmi
Austin James Puchany, Department of Anesthesiology & Perioperative Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States
Ibtesam Hilmi, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, United States
Ibtesam Hilmi, Department of Anesthesiology and Perioperative Medicine, Clinical and Translational Science Institute, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, United States
Author contributions: Puchany AJ performed literature review, writing – original draft; Hilmi I performed conceptualization, review, and editing.
Conflict-of-interest statement: Both authors have nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ibtesam Hilmi, FRCA, MBChB, Doctor, Professor, School of Medicine, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, United States.hilmiia@upmc.edu
Received: September 26, 2024
Revised: November 22, 2024
Accepted: December 19, 2024
Published online: June 9, 2025
Processing time: 154 Days and 7.8 Hours
Core Tip

Core Tip: In this article, we review the newest updates in the definition, pathophysiology and risk factors for post-reperfusion syndrome (PRS). We discuss the latest recommendations for management of PRS. We analyze and the novel advances in liver donor preservation and their potential impact on prevention of PRS.