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World J Crit Care Med. Dec 9, 2024; 13(4): 96482
Published online Dec 9, 2024. doi: 10.5492/wjccm.v13.i4.96482
Clinical prediction scores predicting weaning failure from invasive mechanical ventilation: Role and limitations
Anish Gupta, Omender Singh, Deven Juneja
Anish Gupta, Institute of Critical Care Medicine, Max Hospital, Gurugram 122022, Haryana, India
Omender Singh, Deven Juneja, Institute of Critical Care Medicine, Max Super Specialty Hospital, New Delhi 110017, India
Author contributions: Gupta A and Juneja D conceived the study, performed data acquisition, carried out the majority of writing, and prepared the tables; Singh O provided inputs in writing of the paper and reviewed the manuscript.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Deven Juneja, DNB, FRCP, MBBS, Director, Institute of Critical Care Medicine, Max Super Specialty Hospital, 1 Press Enclave Road, Saket, New Delhi 110017, India. devenjuneja@gmail.com
Received: May 7, 2024
Revised: August 27, 2024
Accepted: August 30, 2024
Published online: December 9, 2024
Processing time: 176 Days and 15.6 Hours
Core Tip

Core Tip: Delay in weaning from invasive mechanical ventilation or weaning failure (WF) may increase patient mortality, morbidity, risk of secondary infections, length of hospital/ICU stay and healthcare costs. Physician’s ability to predict successful weaning has been shown to have low accuracy, with poor positive and negative predictive values. As the pathophysiology of WF is complex and multifactorial, a single parameter may not suffice to predict successful weaning. Hence, several clinical scores, encompassing multiple patients and ventilatory factors have been devised to predict WF. However, none of the current scores is ideal and each have their inherent limitations.