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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Sep 9, 2024; 13(3): 96132
Published online Sep 9, 2024. doi: 10.5492/wjccm.v13.i3.96132
Published online Sep 9, 2024. doi: 10.5492/wjccm.v13.i3.96132
Low T3 vs low T3T4 euthyroid sick syndrome in septic shock patients: A prospective observational cohort study
Mirza Kovacevic, Department of Anesthesiology, Resuscitation and Intensive Care, Cantonal Hospital, Zenica 72000, Bosnia and Herzegovina
Visnja Nesek-Adam, Department of Anesthesiology, Resuscitation and Intensive Care, Clinical Hospital Sveti Duh, Zagreb 10000, Croatia
Semir Klokic, Gruppenpraxis, General Practitioner's Office, Laufen 4242, Switzerland
Ekrema Mujaric, Department of Internal Diseases, Cantonal Hospital, Zenica 72000, Bosnia and Herzegovina
Author contributions: Kovacevic M, Nesek-Adam V contributed to the conception of idea, manuscript draft, revision and critical review; Klokic S and Mujaric E contributed to manuscript revision, figure selection and critical review.
Institutional review board statement: This study was approved by the Institutional Review Board (IRB) of Cantonal Hospital Zenica, and the protocols used in the study were approved by the Ethical Committee of Cantonal Hospital Zenica (00-03-35-38-14/22).
Clinical trial registration statement: This study is registered at ClinTrials.gov. The registration identification number is NCT06242626.
Informed consent statement: All data in the study were used after obtaining informed written consent from the patient.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All data underlying the results are available as part of the article and no additional source data are required.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mirza Kovacevic, PhD, Postdoc, Department of Anesthesiology, Resu
Received: April 27, 2024
Revised: June 8, 2024
Accepted: June 24, 2024
Published online: September 9, 2024
Processing time: 124 Days and 8 Hours
Revised: June 8, 2024
Accepted: June 24, 2024
Published online: September 9, 2024
Processing time: 124 Days and 8 Hours
Core Tip
Core Tip: Euthyroid sick syndrome (ESS) is a significant clinical condition that greatly alters mortality in septic shock patients. Low values of T3 hormone levels have previously been associated with adaptation, while the condition with low T3 and T4 levels are still insufficiently known in terms of the impact on mortality and other pathophysiological mechanisms. This prospective study will give readers knowledge about the two types of ESS, and therefore new insight into hormonal disturbances in septic shock patients with possible thyroid hormone supplementation in the low T3T4 phase.