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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Jun 9, 2024; 13(2): 91225
Published online Jun 9, 2024. doi: 10.5492/wjccm.v13.i2.91225
Published online Jun 9, 2024. doi: 10.5492/wjccm.v13.i2.91225
Steroids in acute respiratory distress syndrome: A panacea or still a puzzle?
Sharmili Sinha, Department of Critical Care Medicine, Apollo Hospitals, Bhubaneswar 751005, Odisha, India
Rohit Patnaik, Department of Critical Care Medicine, Medeor 24x7 Hospital, Al Danah 40330, Abu Dhabi, United Arab Emirates
Srikant Behera, Department of Internal Medicine and Critical Care, All India Institute of Medical Sciences, Bhubaneswar 751019, Odisha, India
Author contributions: Sinha S conceived the idea; Sinha S, Patnaik R and Behera S performed literature search; Sinha S and Patnaik R wrote the paper; All authors reviewed the language before submission.
Conflict-of-interest statement: All authors have no conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sharmili Sinha, MD, Adjunct Associate Professor, Department of Critical Care Medicine, Apollo Hospitals, Bhubaneswar 751005, Odisha, India.
Received: December 25, 2023
Revised: April 28, 2024
Accepted: May 15, 2024
Published online: June 9, 2024
Processing time: 161 Days and 2 Hours
Revised: April 28, 2024
Accepted: May 15, 2024
Published online: June 9, 2024
Processing time: 161 Days and 2 Hours
Core Tip
Core Tip: Acute respiratory distress syndrome (ARDS) was described in 1967. For decades, various pharmacotherapies, including corticosteroids, have been examined for treatment, with corticosteroids showing potential for improving outcomes. However, corticosteroids have potential adverse effects including hospital-acquired infections and intensive care unit acquired weakness. The authors have analysed and reviewed the existing evidence regarding the role of corticosteroids in the management of community acquired pneumonia with respiratory failure, coronavirus disease 2019 pneumonia, septic shock and ARDS.