Minireviews
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Jun 9, 2023; 12(3): 116-129
Published online Jun 9, 2023. doi: 10.5492/wjccm.v12.i3.116
Approaches to neuroprotection in pediatric neurocritical care
Angad Kochar, Kara Hildebrandt, Rebecca Silverstein, Brian Appavu
Angad Kochar, Kara Hildebrandt, Rebecca Silverstein, Brian Appavu, Department of Neurosciences, Phoenix Children's Hospital, Phoenix, AZ 85213, United States
Brian Appavu, Child Health, University of Arizona College of Medicine - Phoenix, Phoenix, AZ 85016, United States
Author contributions: Kochar A, Hildebrandt K, Silverstein R and Appavu B contributed to the conception of this review, analysis of the data, and writing of the manuscript, and all authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Brian Appavu, MD, Assistant Professor, Department of Neurosciences, Phoenix Children's Hospital, 1919 E. Thomas Road, Ambulatory Building B, 4th Floor, Phoenix, AZ 85016, United States. bappavu@phoenixchildrens.com
Received: December 28, 2022
Peer-review started: December 28, 2022
First decision: March 1, 2023
Revised: March 30, 2023
Accepted: April 12, 2023
Article in press: April 12, 2023
Published online: June 9, 2023
Core Tip

Core Tip: Acute neurologic injuries are a common cause of morbidity and mortality in critically ill children. A fundamental goal of pediatric neurocritical care is to mitigate the impact of secondary neurologic injury in critically ill children. Here, we discuss strategies for optimizing neuroprotective strategies in critically ill children.