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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Jan 9, 2023; 12(1): 18-28
Published online Jan 9, 2023. doi: 10.5492/wjccm.v12.i1.18
Published online Jan 9, 2023. doi: 10.5492/wjccm.v12.i1.18
Clonidine use during dexmedetomidine weaning: A systematic review
Sanu Rajendraprasad, Department of Pulmonary & Critical Care, Mayo Clinic, Rochester, MN 55905, United States
Molly Wheeler, Erin Wieruszewski, Patrick M Wieruszewski, Department of Pharmacy, Mayo Clinic, Rochester, MN 55905, United States
Joseph Gottwald, Nathan J Smischney, Department of Anesthesiology & Perioperative Medicine, Mayo Clinic, Rochester, MN 55905, United States
Lindsey A. Wallace, Critical Care Medicine Independent Multidisciplinary Program, Mayo Clinic, Rochester, MN 55905, United States
Danielle Gerberi, Mayo Medical Libraries, Mayo Clinic, Rochester, MN 55905, United States
Author contributions: Rajendraprasad S, Wieruszewski P, and Smischney N designed the research; Rajendraprasad S, Wheeler M, and Wieruszewski E performed the research; Gottwald J and Wallace L analyzed the data; Rajendraprasad S, Wheeler M, Gottwald J, Wallace L, Wieruszewski P, and Smischney N drafted the paper; All authors reviewed and edited the manuscript and approved the final version.
Conflict-of-interest statement: All authors declare no conflicts of interest.
PRISMA 2009 Checklist statement: The study followed the PRISMA guidelines. The protocol was a priori registered in the PROSPERO database (No. CRD42022330666).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nathan J Smischney, MD, MS, Associate Professor, Department of Anesthesiology & Perioperative Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States. smischney.nathan@mayo.edu
Received: September 13, 2022
Peer-review started: September 13, 2022
First decision: October 21, 2022
Revised: November 15, 2022
Accepted: November 30, 2022
Article in press: November 30, 2022
Published online: January 9, 2023
Processing time: 111 Days and 10.5 Hours
Peer-review started: September 13, 2022
First decision: October 21, 2022
Revised: November 15, 2022
Accepted: November 30, 2022
Article in press: November 30, 2022
Published online: January 9, 2023
Processing time: 111 Days and 10.5 Hours
Core Tip
Core Tip: In this systematic review of enteral clonidine use during dexmedetomidine weaning in critically ill patients, an association of increased withdrawal symptoms and agitation with the use of a clonidine taper and no difference in intensive care unit length of stay with or without clonidine taper was observed. However, varied techniques and a small total sample size restrict utility of the findings.