Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Crit Care Med. Jul 9, 2021; 10(4): 66-80
Published online Jul 9, 2021. doi: 10.5492/wjccm.v10.i4.66
Sepsis: Evidence-based pathogenesis and treatment
Jay Pravda
Jay Pravda, Inflammatory Disease Research Centre, Therashock LLC, Palm Beach Gardens, FL 33410, United States
Author contributions: Pravda J solely contributed to this manuscript.
Conflict-of-interest statement: The author has no any conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jay Pravda, MD, Research Scientist, Inflammatory Disease Research Centre, Therashock LLC, 4371 Northlake Blvd No. 247, Palm Beach Gardens, FL 33410, United States. jaypravda1@gmail.com
Received: February 9, 2021
Peer-review started: February 10, 2021
First decision: March 31, 2021
Revised: April 13, 2021
Accepted: June 2, 2021
Article in press: June 2, 2021
Published online: July 9, 2021
Processing time: 147 Days and 0 Hours
Core Tip

Core Tip: Sepsis mortality remains unacceptably high because there is no specific treatment to prevent or reverse the multiple organ failure and refractory hypotension that develops in this condition. An evidence-based analysis suggests that impaired systemic redox homeostasis caused by the toxic accumulation of hydrogen peroxide has a causal role in the pathogenesis of this often fatal illness. The data imply that restoration of redox homeostasis by therapeutic reduction of hydrogen peroxide will significantly reduce the morbidity and mortality associated with sepsis. A therapeutic intervention to reduce systemic levels of hydrogen peroxide is presented.