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World J Crit Care Med. Sep 9, 2024; 13(3): 95781
Published online Sep 9, 2024. doi: 10.5492/wjccm.v13.i3.95781
Impact of different intravenous bolus rates on fluid and electrolyte balance and mortality in critically ill patients
Mutaz I Othman, Emad M Mustafa, Moayad Alfayoumi, Mohamad Y Khatib, Abdulqadir J Nashwan
Mutaz I Othman, Emad M Mustafa, Abdulqadir J Nashwan, Department of Nursing, Hamad Medical Corporation, Doha 3050, Qatar
Moayad Alfayoumi, Department of Pharmacy, Hamad Medical Corporation, Doha 3050, Qatar
Mohamad Y Khatib, Department of Critical Care, Hamad Medical Corporation, Doha 3050, Qatar
Author contributions: Othman MI, Mustafa EM, Alfayoumi M, Khatib MY, Nashwan AJ were involved in conceptualization, methods, literature search, and manuscript preparation; all authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Abdulqadir J Nashwan, PhD, Research Scientist, Department of Nursing, Hamad Medical Corporation, Rayyan Road, Doha 3050, Qatar. anashwan@hamad.qa
Received: April 18, 2024
Revised: July 23, 2024
Accepted: August 9, 2024
Published online: September 9, 2024
Processing time: 133 Days and 15.7 Hours
Abstract

The effect of intravenous bolus rates on patient outcomes is a complex and crucial aspect of critical care. Fluid challenges are commonly used in critically ill patients to manage their hemodynamic status, but there is limited information available on the specifics of when, how much, and at what rate fluids should be administered during these challenges. The aim of this review is to thoroughly examine the relationship between intravenous bolus rates, fluid-electrolyte balance, and mortality and to analyze key research findings and methodologies to understand these complex dynamics better. Fluid challenges are commonly employed in managing hemodynamic status in this population, yet there is limited information on the optimal timing, volume, and rate of fluid administration. Utilizing a narrative review approach, the analysis identified nine relevant studies that investigate these variables. The findings underscore the importance of a precise and individualized approach in clinical settings, highlighting the need to tailor intravenous bolus rates to each patient's specific needs to maximize outcomes. This review provides valuable insights that can inform and optimize clinical practices in critical care, emphasizing the necessity of meticulous and exact strategies in fluid administration.

Keywords: Fluid balance; Fluid resuscitation; Intensive care unit; Precision medicine; Mortality

Core Tip: This review aims to emphasize the importance of a meticulous and exact approach in medical settings, focusing on tailoring intravenous bolus rates to suit the specific needs of individual patients. This review seeks to provide valuable insights that can inform and optimize clinical practices in the critical care setting by maximizing desired outcomes through tailored strategies.