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Copyright ©2014 Baishideng Publishing Group Co.
World J Immunol. Mar 27, 2014; 4(1): 26-33
Published online Mar 27, 2014. doi: 10.5411/wji.v4.i1.26
Table 1 Myeloid-derived suppressor cells in autoimmune disease models
Human diseaseMouse modelPhenotypeT cell suppressionSuppressive mechanismSuppressive role in vivo
Multiple sclerosisEAECD11b+Ly6Chigh (M-MDSCs)CD4+ T cellsNO-apoptosisNot determined[18]
EAECD11b+Ly6G- (M-MDSCs)CD4+, CD8+, Ag-specific CD4+ T cellsNOSNo effect by naïve MDSCs[77]
EAECD11b+Ly6Chigh (M-MDSCs)Not determinedNot determinedIncrease severity[73]
EAEArg-1+CD11b+Gr-1low (M-MDSCs)CD3+ T cellsApoptosisNot determined[10]
EAECD11b+Ly6C+ (M-MDSCs)CD4+ T cellsNOReduce severity by late phase MDSCs[34]
EAECD11bhighLy6G+Ly6C- (G-MDSCs)Th1 and Th17 cellsPD-L1Reduce severity[12]
EAECD11b+Gr-1+Promote Th17 cellsIL-1βIncrease severity[33]
EAECD11b+Gr-1+Ag-specific Th17 cellsiNOS, arginase-1 and IL-10Ablated iNKT-induced disease mitigation[78]
Rheumatoid arthritisCIACD11b+Ly6C+Ly6G- (M-MDSC)CD4+ T cellsNOReduce severity[41]
CIACD11b+Gr-1+Th17 cellsArginase and iNOSReduce severity[11]
Proteoglycan- induced arthritisCD11b+Gr-1+Ag-specific T cellsNO and ROSNot determined[79]
Systemic lupus erythematosusMRL-faslprCD11b+Gr-1low (M-MDSCs)CD4+ T cellsArginase-1Not determined[80]
Inflammatory bowel diseaseHA-transgenic miceCD11b+Gr-1+Ag-specific CD8+ T cellsNO-apoptosisReduce severity[14]
DDS-induced colitisCD11b+Gr-1+Not determinedNot determinedReduce severity[75]
IL-10-/-CD11b+Gr-1+MLN T cellsNot determinedNot determined[81]
TNBS-induced colitisCD11b+Gr-1+SplenocytesNot determinedReduce severity[74]
T1DINS-HA/ RAG-/-Gr-1+CD115+ (M-MDSCs)Induce Tregs and inhibit Teff cellsTGF-β and IL-10Reduce severity[54]
h-CD20/NODCD11b+Gr-1+CD4+ and CD8+ T cells induce TregsNO and IL-10Not determined[32]
Autoimmune hepatitisTgfb-/-CD11b+Ly6Chigh Ly6G- (M-MDSCs)CD4+ T cellsNONot determined[82]
Inflammatory eye diseaseEAUCD11b+Gr-1+ Ly6G- (M-MDSCs)CD4+ T cellsTNFR-dependent, ArginaseNot Determined[9]
EAUREP-induced CD11b+Gr-1+CD4+ T cellsNot determinedReduce severity[76]
Alopecia areataAlopecia areata-eczemaCD11b+Gr-1+CD4+ and CD8+ T cellsCD3-zeta down-regulationLocal MDSC administration reduces severity[83]