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©2014 Baishideng Publishing Group Co.
World J Immunol. Mar 27, 2014; 4(1): 26-33
Published online Mar 27, 2014. doi: 10.5411/wji.v4.i1.26
Published online Mar 27, 2014. doi: 10.5411/wji.v4.i1.26
Human disease | Mouse model | Phenotype | T cell suppression | Suppressive mechanism | Suppressive role in vivo |
Multiple sclerosis | EAE | CD11b+Ly6Chigh (M-MDSCs) | CD4+ T cells | NO-apoptosis | Not determined[18] |
EAE | CD11b+Ly6G- (M-MDSCs) | CD4+, CD8+, Ag-specific CD4+ T cells | NOS | No effect by naïve MDSCs[77] | |
EAE | CD11b+Ly6Chigh (M-MDSCs) | Not determined | Not determined | Increase severity[73] | |
EAE | Arg-1+CD11b+Gr-1low (M-MDSCs) | CD3+ T cells | Apoptosis | Not determined[10] | |
EAE | CD11b+Ly6C+ (M-MDSCs) | CD4+ T cells | NO | Reduce severity by late phase MDSCs[34] | |
EAE | CD11bhighLy6G+Ly6C- (G-MDSCs) | Th1 and Th17 cells | PD-L1 | Reduce severity[12] | |
EAE | CD11b+Gr-1+ | Promote Th17 cells | IL-1β | Increase severity[33] | |
EAE | CD11b+Gr-1+ | Ag-specific Th17 cells | iNOS, arginase-1 and IL-10 | Ablated iNKT-induced disease mitigation[78] | |
Rheumatoid arthritis | CIA | CD11b+Ly6C+Ly6G- (M-MDSC) | CD4+ T cells | NO | Reduce severity[41] |
CIA | CD11b+Gr-1+ | Th17 cells | Arginase and iNOS | Reduce severity[11] | |
Proteoglycan- induced arthritis | CD11b+Gr-1+ | Ag-specific T cells | NO and ROS | Not determined[79] | |
Systemic lupus erythematosus | MRL-faslpr | CD11b+Gr-1low (M-MDSCs) | CD4+ T cells | Arginase-1 | Not determined[80] |
Inflammatory bowel disease | HA-transgenic mice | CD11b+Gr-1+ | Ag-specific CD8+ T cells | NO-apoptosis | Reduce severity[14] |
DDS-induced colitis | CD11b+Gr-1+ | Not determined | Not determined | Reduce severity[75] | |
IL-10-/- | CD11b+Gr-1+ | MLN T cells | Not determined | Not determined[81] | |
TNBS-induced colitis | CD11b+Gr-1+ | Splenocytes | Not determined | Reduce severity[74] | |
T1D | INS-HA/ RAG-/- | Gr-1+CD115+ (M-MDSCs) | Induce Tregs and inhibit Teff cells | TGF-β and IL-10 | Reduce severity[54] |
h-CD20/NOD | CD11b+Gr-1+ | CD4+ and CD8+ T cells induce Tregs | NO and IL-10 | Not determined[32] | |
Autoimmune hepatitis | Tgfb-/- | CD11b+Ly6Chigh Ly6G- (M-MDSCs) | CD4+ T cells | NO | Not determined[82] |
Inflammatory eye disease | EAU | CD11b+Gr-1+ Ly6G- (M-MDSCs) | CD4+ T cells | TNFR-dependent, Arginase | Not Determined[9] |
EAU | REP-induced CD11b+Gr-1+ | CD4+ T cells | Not determined | Reduce severity[76] | |
Alopecia areata | Alopecia areata-eczema | CD11b+Gr-1+ | CD4+ and CD8+ T cells | CD3-zeta down-regulation | Local MDSC administration reduces severity[83] |
- Citation: Crook KR, Liu P. Role of myeloid-derived suppressor cells in autoimmune disease. World J Immunol 2014; 4(1): 26-33
- URL: https://www.wjgnet.com/2219-2824/full/v4/i1/26.htm
- DOI: https://dx.doi.org/10.5411/wji.v4.i1.26