Revised: December 12, 2013
Accepted: January 17, 2014
Published online: March 27, 2014
Processing time: 152 Days and 7.6 Hours
Myeloid-derived suppressor cells (MDSCs) represent an important class of immunoregulatory cells that can be activated to suppress T cell functions. These MDSCs can inhibit T cell functions through cell surface interactions and the release of soluble mediators. MDSCs accumulate in the inflamed tissues and lymphoid organs of patients with autoimmune diseases. Much of our knowledge of MDSC function has come from studies involving cancer models, however many recent studies have helped to characterize MDSC involvement in autoimmune diseases. MDSCs are a heterogeneous group of immature myeloid cells with a number of different functions for the suppression of T cell responses. However, we have yet to fully understand their contributions to the development and regulation of autoimmune diseases. A number of studies have described beneficial functions of MDSCs during autoimmune diseases, and thus there appears to be a potential role for MDSCs in the treatment of these diseases. Nevertheless, many questions remain as to the activation, differentiation, and inhibitory functions of MDSCs. This review aims to summarize our current knowledge of MDSC subsets and suppressive functions in tissue-specific autoimmune disorders. We also describe the potential of MDSC-based cell therapy for the treatment of autoimmune diseases and note some of hurdles facing the implementation of this therapy.
Core tip: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of cells with immunosuppressive abilities. MDSCs inhibit T cell function and regulate immune responses in cancer and autoimmune diseases. Therapeutic administration of MDSCs in the mouse models of multiple sclerosis, rheumatoid arthritis, and diabetes has shown promising results. Thus, MDSCs have potential in cell-based treatments of autoimmune disorders. However, the role of MDSCs in autoimmunity is complex and not fully understood. Further studies are needed before new therapies can be implemented.