Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Role of tumor associated macrophages in regulating pancreatic cancer progression
Raul Caso, NYU School of Medicine, NYU Langone Medical Center, New York, NY 10016, United States
George Miller, Departments of Surgery and Cell Biology, NYU Langone Medical Center, New York, NY 10016, United States
Author contributions: Both authors contributed to this manuscript.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: George Miller, MD, Departments of Surgery and Cell Biology, NYU Langone Medical Center, 430 E. 29th St., Suite 660, New York, NY 10016, United States. george.miller@nyumc.org
Telephone: +1-646-5012208 Fax: +1-646-5014564
Received: July 28, 2015
Peer-review started: July 29, 2015
First decision: October 13, 2015
Revised: December 8, 2015
Accepted: December 29, 2015
Article in press: January 4, 2016
Published online: March 27, 2016
Processing time: 244 Days and 7.1 Hours
Peer-review started: July 29, 2015
First decision: October 13, 2015
Revised: December 8, 2015
Accepted: December 29, 2015
Article in press: January 4, 2016
Published online: March 27, 2016
Processing time: 244 Days and 7.1 Hours
Core Tip
Core tip: Pancreatic cancer remains one of the most deadly cancers with dismal 5-year survival rates. Increasing importance is being given to the role of macrophages in pancreatic cancer. Tumor-associated promote angiogenesis, metastasis, and suppress the anti-tumor immune response. Targeting macrophages within the tumor microenvironment is an attractive novel therapeutic approach. Here we review the current understanding of the role of tumor-associated macrophages in the progression of pancreatic cancer.