Goswami R, Kaplan MH. Essential vitamins for an effective T cell response. World J Immunol 2016; 6(1): 39-59 [DOI: 10.5411/wji.v6.i1.39]
Corresponding Author of This Article
Ritobrata Goswami, PhD, Institute of Life Sciences, Ahmedabad University, University Road, Navrangpura, Ahmedabad 380009, Gujarat, India. ritobrata.goswami@ahduni.edu.in
Research Domain of This Article
Immunology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Immunol. Mar 27, 2016; 6(1): 39-59 Published online Mar 27, 2016. doi: 10.5411/wji.v6.i1.39
Essential vitamins for an effective T cell response
Ritobrata Goswami, Mark H Kaplan
Ritobrata Goswami, Institute of Life Sciences, Ahmedabad University, Ahmedabad 380009, Gujarat, India
Mark H Kaplan, Department of Pediatrics, Wells Center for Pediatric Research, Indiana University, Indianapolis, IN 46224, United States
Author contributions: Goswami R and Kaplan MH wrote the paper.
Conflict-of-interest statement: Authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ritobrata Goswami, PhD, Institute of Life Sciences, Ahmedabad University, University Road, Navrangpura, Ahmedabad 380009, Gujarat, India. ritobrata.goswami@ahduni.edu.in
Received: July 8, 2015 Peer-review started: July 14, 2015 First decision: September 22, 2015 Revised: October 24, 2015 Accepted: November 23, 2015 Article in press: November 25, 2015 Published online: March 27, 2016 Processing time: 263 Days and 9.8 Hours
Core Tip
Core tip: Vitamins are organic compounds that are required in small quantities as nutrients. When used as dietary supplements, vitamins can be used to treat diseases and maintain physiological processes including bone and skin health. Vitamins also play important roles in immune system including lymphocyte activation, and T helper cell differentiation. Among all the vitamins, vitamin A and D have garnered more interest in clinical setting. In this review we have focused on how vitamin A and D regulate adaptive immunity especially how both the vitamins modulate T cell responses. We have highlighted the mechanisms how these vitamins affect T helper cell differentiation. How these vitamins affect inflammatory disorders including allergy and autoimmune diseases have also been described in this review. The purpose of this review is to suggest the potential of dietary supplements such as vitamin A and D can be used to treat inflammatory disorders.
