Stubljar D, Skvarc M. Helicobacter pylori vs immune system or antibiotics. World J Immunol 2015; 5(3): 142-151 [DOI: 10.5411/wji.v5.i3.142]
Corresponding Author of This Article
David Stubljar, BSc, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia. d.stubljar@gmail.com
Research Domain of This Article
Immunology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Immunol. Nov 27, 2015; 5(3): 142-151 Published online Nov 27, 2015. doi: 10.5411/wji.v5.i3.142
Helicobacter pylori vs immune system or antibiotics
David Stubljar, Miha Skvarc
David Stubljar, Miha Skvarc, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia
Author contributions: Stubljar D designed and wrote the manuscript; Skvarc M was involved in revising the manuscript critically and gave final approval of the manuscript to be published.
Conflict-of-interest statement: Authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: David Stubljar, BSc, Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloska 4, 1000 Ljubljana, Slovenia. d.stubljar@gmail.com
Telephone: +386-15-437494 Fax: +386-15-437485
Received: April 28, 2015 Peer-review started: April 29, 2015 First decision: June 3, 2015 Revised: June 18, 2015 Accepted: July 24, 2015 Article in press: July 27, 2015 Published online: November 27, 2015 Processing time: 213 Days and 14.2 Hours
Core Tip
Core tip: Combination of Helicobacter pylori (H. pylori) and host-associated risk factors do not always allow evaluation of gastric carcinoma. We have learnt that the assessment of patients with H. pylori infection and its strain is very important and concluded that eradication of bacteria has essential meaning. We recommend that not only screening for H. pylori also the strain determination should have some diagnostic value, especially in the patients who already developed gastritis. Furthermore, for such patients assessment of disease progression could be followed by polymorphism determination. Conclusions indicate that host cytokine genotypes, host immune response, as well as H. pylori strains could be important for greater risk for developing gastric cancer.
