Varela-Calviño R, Cordero OJ. Stem and immune cells in colorectal primary tumour: Number and function of subsets may diagnose metastasis. World J Immunol 2015; 5(2): 68-77 [DOI: 10.5411/wji.v5.i2.68]
Corresponding Author of This Article
Oscar J Cordero, PhD, Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, CIBUS Building, Campus Vida, 15782 Santiago de Compostela, Spain. oscarj.cordero@usc.es
Research Domain of This Article
Oncology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Immunol. Jul 27, 2015; 5(2): 68-77 Published online Jul 27, 2015. doi: 10.5411/wji.v5.i2.68
Stem and immune cells in colorectal primary tumour: Number and function of subsets may diagnose metastasis
Rubén Varela-Calviño, Oscar J Cordero
Rubén Varela-Calviño, Oscar J Cordero, Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
Author contributions: Varela-Calviño R and Cordero OJ wrote and edited the manuscript.
Conflict-of-interest statement: The authors declare that they do not have potential financial conflict of interest related to this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Oscar J Cordero, PhD, Department of Biochemistry and Molecular Biology, University of Santiago de Compostela, CIBUS Building, Campus Vida, 15782 Santiago de Compostela, Spain. oscarj.cordero@usc.es
Telephone: +34-881-816935
Received: January 20, 2015 Peer-review started: January 22, 2015 First decision: March 6, 2015 Revised: May 20, 2015 Accepted: July 16, 2015 Article in press: July 17, 2015 Published online: July 27, 2015 Processing time: 195 Days and 14 Hours
Core Tip
Core tip: Metastasis relies on differentiation of some cancer stem cells in the primary tumour niche led by many micro-environmental signals. These signals include the participation of immune cell subsets such as tumour-infiltrating lymphocytes, dendritic cells and regulatory populations. Metastatic stem cells can be identified in the removed primary tumour. The study of the number and function of these immune cell populations in parallel with metastatic stem cells (MetSCs) in the primary tumour, together with follow-up data of patients, will define the usefulness of specific immune and MetSCs cell population combinations. This can be combined with defining new biomarkers as future predictors of tumour recurrences, metastases and/or mortality in colorectal cancer.
