Yan C, Du H. Lysosomal acid lipase is critical for myeloid-derived suppressive cell differentiation, development, and homeostasis. World J Immunol 2014; 4(2): 42-51 [DOI: 10.5411/wji.v4.i2.42]
Corresponding Author of This Article
Dr. Cong Yan, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 975 W Walnut Street, IB424G, Indianapolis, IN 46202, United States. coyan@iupui.edu
Research Domain of This Article
Immunology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Immunol. Jul 27, 2014; 4(2): 42-51 Published online Jul 27, 2014. doi: 10.5411/wji.v4.i2.42
Lysosomal acid lipase is critical for myeloid-derived suppressive cell differentiation, development, and homeostasis
Cong Yan, Hong Du
Cong Yan, Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, United States
Cong Yan, Hong Du, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, United States
Cong Yan, Hong Du, IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, United States
Author contributions: Yan C and Du H wrote and edited the review.
Supported by National Institutes of Health, No.CA138759, CA152099, to Yan C; HL087001, to Du H, and HL-061803 and HL-067862 to Yan C and Du H
Correspondence to: Dr. Cong Yan, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 975 W Walnut Street, IB424G, Indianapolis, IN 46202, United States. coyan@iupui.edu
Telephone: +1-317-2786005 Fax: +1-317-2788198
Received: February 26, 2014 Revised: April 2, 2014 Accepted: June 18, 2014 Published online: July 27, 2014 Processing time: 151 Days and 13.4 Hours
Core Tip
Core tip: Neutral lipid metabolism is essential for myeloid cell proliferation and differentiation. This review summarizes the most recent discoveries that lysosomal acid lipase (LAL), an enzyme hydrolysing cholesteryl esters and triglycerides in lysosomes, plays a critical role in myeloid-derived suppressive cells (MDSCs) development, differentiation, and immune suppressive function. Both LAL knock-out and myeloid specific rescue of LAL knock-out mice are used in the studies. Doxycycline-inducible bitransgenic mouse models of LAL downstream genes are also generated to study MDSCs malformation and malfunction. The molecular pathways/mechanisms to connect LAL and MDSCs are characterized by microarray analyses of gene transcriptional profiles.
