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Cigarette smoking and innate immune responses to influenza infection
Wenxin Wu, Jordan P Metcalf, Department of Medicine, Pulmonary and Critical Care Division, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States
Jordan P Metcalf, Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States
Author contributions: Wu W and Metcalf JP wrote the review.
Supported by The Oklahoma Health Research Program from Oklahoma Center for the Advancement of Science and Technology, to Wu W; and by the National Institute of Allergy and Infectious Diseases, No. 1U19 AI62629, to Metcalf JP
Correspondence to: Wenxin Wu, PhD, Department of Medicine, Pulmonary and Critical Care Division, University of Oklahoma Health Sciences Center, 800 Research Pkwy, RP1, Rm 425, Oklahoma City, OK 73104, United States. wenxin-wu@ouhsc.edu
Telephone: +1-405-2711966 Fax: +1-405-2715440
Received: October 31, 2013
Revised: December 18, 2013
Accepted: February 16, 2014
Published online: March 27, 2014
Processing time: 146 Days and 13.5 Hours
Revised: December 18, 2013
Accepted: February 16, 2014
Published online: March 27, 2014
Processing time: 146 Days and 13.5 Hours
Core Tip
Core tip: Cigarette smoking (CS) alters a wide range of immunological functions, including innate and adaptive immune responses to viral infection. This review aims to give a brief summary of recent findings on the suppressive effects of CS on the innate response to influenza virus, especially as it pertains to suppression of the function of pattern recognition receptors for influenza virus. Studies on CS inhibition to innate response will be important in designing strategies for the development of novel treatments to mitigate the adverse consequences of CS and Flu infection.