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Immune response after photodynamic therapy increases anti-cancer and anti-bacterial effects
Eleonora Reginato, Michael R Hamblin, Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, United States
Eleonora Reginato, Peter Wolf, Department of Dermatology, Medical University of Graz, Graz 8036, Austria
Michael R Hamblin, Department of Dermatology, Harvard Medical School, Boston, MA 02115, United States
Michael R Hamblin, Harvard-MIT Division of Health Science and Technology, Boston, MA 02139, United States
Author contributions: All authors contributed to this paper.
Supported by United States National Institute of Health grant AI050875; the PhD program of the Medical University of Graz, Austria, to Reginato E
Correspondence to: Michael R Hamblin, PhD, Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, United States. hamblin@helix.mgh.harvard.edu
Telephone: +1-617-7266182 Fax: +1-617-7266566
Received: October 17, 2013
Revised: December 20, 2013
Accepted: February 16, 2014
Published online: March 27, 2014
Processing time: 159 Days and 19.2 Hours
Revised: December 20, 2013
Accepted: February 16, 2014
Published online: March 27, 2014
Processing time: 159 Days and 19.2 Hours
Core Tip
Core tip: The immune stimulatory properties of photodynamic therapy (PDT) make this therapy one of the most promising therapeutic procedures for the management of cancer lesions and microbial infections. This review will focus on the current knowledge of the innate and adaptive immune responses induced by PDT against tumors and pathogens.