Minireviews
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Immunol. Aug 24, 2022; 12(2): 15-24
Published online Aug 24, 2022. doi: 10.5411/wji.v12.i2.15
Probiotic treatment of inflammatory bowel disease: Its extent and intensity
Saheli Biswas, Ena Ray Banerjee
Saheli Biswas, Ena Ray Banerjee, Department of Zoology, University of Calcutta, Kolkata 700019, West Bengal, India
Author contributions: Biswas S has done the review and has written the manuscript; Ray Banerjee E has overall conceptualized, written and guided this manuscript; all authors have approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ena Ray Banerjee, PhD, DSc Professor, Department of Zoology, University of Calcutta, No. 35 Ballygunge Circular Road, Kolkata 700019, West Bengal, India. enarb1@gmail.com
Received: May 2, 2022
Peer-review started: May 2, 2022
First decision: May 31, 2022
Revised: June 9, 2022
Accepted: August 17, 2022
Article in press: August 17, 2022
Published online: August 24, 2022
Processing time: 112 Days and 1.7 Hours
Core Tip

Core tip: Inflammatory bowel diseases (IBDs) are degenerative diseases that cause chronic inflammation in the intestine. The most prevalent therapy for IBD is conventional antibiotic therapy. Keeping the adverse effects of antibiotics in mind, researchers have shown that Streptococcus, Lactobacillus and Bifidobacterium are some of the most efficient antioxidative agents with respect to in vitro and in vivo activities. Probiotics individually or in combination play an important role in regulating superoxide dismutase activity, which is always dysregulated due to oxidative stress caused in IBD. The mechanism of antioxidation of probiotics using NRf2-antioxidative response element pathway, nuclear factor-B and protein kinase C pathway may be activated to contribute to the reduction of oxidative-stress-induced IBD. The review focuses on the antioxidative activities of the specific bacterial strains as therapeutic molecules in IBD. Multiple combinations of probiotic strains have still not been adequately studied. We are currently researching the antioxidative effect of Streptococcus thermophilus, Lactobacillus acidophilus and Bifidobacterium bifidumin combination.