Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
PICOT promotes T lymphocyte proliferation by down-regulating cyclin D2 expression
Pinakin Pandya, Noah Isakov, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
Pinakin Pandya, Department of Computational and System biology, UPMC Hillman Cancer Center, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15232, United States
Author contributions: This manuscript was written and edited by both authors.
Supported by the USA-Israel Binational Science Foundation , No. 2013034; the Israel Science Foundation administered by the Israel Academy of Science, No. 1235/17; the Jacki and Bruce Barron Cancer Research Scholars’ Program, City of Hope and the Israel Cancer Research Fund, No. 87735611 .
Conflict-of-interest statement: The authors have no financial conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Noah Isakov, PhD, Professor, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, P.O.B. 653, Beer Sheva 84105, Israel. noah@bgu.ac.il
Received: January 25, 2020
Peer-review started: January 25, 2020
First decision: April 19, 2020
Revised: May 9, 2020
Accepted: May 12, 2020
Article in press: May 12, 2020
Published online: May 27, 2020
Processing time: 122 Days and 16 Hours
Peer-review started: January 25, 2020
First decision: April 19, 2020
Revised: May 9, 2020
Accepted: May 12, 2020
Article in press: May 12, 2020
Published online: May 27, 2020
Processing time: 122 Days and 16 Hours
Core Tip
Core tip: Protein kinase C-interacting cousin of thioredoxin (PICOT) is a cell growth-regulating protein that interacts with embryonic ectoderm development, a core component of the polycomb repressive complex 2. PICOT is able to alter the extent of the tri-methylation of histone 3 lysine 27 at the promoter region of the polycomb repressive complex 2 target gene, CCND2, which encodes the cell cycle-regulating protein, cyclin D2. High expression levels of PICOT correlates with low expression levels of CCND2 and poor survival of a large number of human cancer patients. The results suggest that a high PICOT/CCND2 expression level ratio might serve as a predictor of patient survival in selected types of human cancer.