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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Immunol. Nov 27, 2016; 6(3): 126-130
Published online Nov 27, 2016. doi: 10.5411/wji.v6.i3.126
Published online Nov 27, 2016. doi: 10.5411/wji.v6.i3.126
IgE regulates airway smooth muscle phenotype: Future perspectives in allergic asthma
Naresh Singh Redhu, Division of GI/Nutrition, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, United States
Abdelilah S Gounni, Department of Immunology, Faculty of Health Sciences, College of Medicine, University of Manitoba, Winnipeg, MB R3E0T5, Canada
Author contributions: Redhu NS and Gounni AS conceptualized, drafted, and revised the full manuscript.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Abdelilah S Gounni, PhD, Professor, Department of Immunology, Faculty of Health Sciences, College of Medicine, University of Manitoba, 419 Apotex Centre, 750 McDermot Ave, Winnipeg, MB R3E0T5, Canada. abdel.gounni@umanitoba.ca
Telephone: +1-204-9757750 Fax: +1-204-7893921
Received: May 21, 2016
Peer-review started: May 22, 2016
First decision: July 30, 2016
Revised: August 15, 2016
Accepted: October 25, 2016
Article in press: October 27, 2016
Published online: November 27, 2016
Processing time: 187 Days and 11.1 Hours
Peer-review started: May 22, 2016
First decision: July 30, 2016
Revised: August 15, 2016
Accepted: October 25, 2016
Article in press: October 27, 2016
Published online: November 27, 2016
Processing time: 187 Days and 11.1 Hours
Abstract
The purpose of this commentary is to highlight the emerging role of IgE on airway smooth muscle (ASM) cells function through activation of the high-affinity Fc receptor for IgE. We discuss the potential implications of IgE-mediated ASM sensitization in airway inflammation and remodeling, the hallmark features of allergic asthma.
Keywords: IgE, Airway, Allergic asthma, Remodeling, Inflammation
Core tip: In this commentary, we summarize the emerging role IgE in influencing airway smooth (ASM) muscle function in allergic asthma. Recent intriguing findings from ours and other groups suggest a potential proinflammatory and pro-remodeling role of IgE-mediated activation of its high-affinity Fc receptor, i.e., FcεRI, on ASM tissue in allergic asthma.