Benefits and risks of erythrocyte-stimulating agents

doi:10.5410/wjcu.v3.i3.258

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World Journal of Clinical Urology

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2219-2816

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Urol. Nov 24, 2014; 3(3): 258-263
Published online Nov 24, 2014. doi: 10.5410/wjcu.v3.i3.258

Benefits and risks of erythrocyte-stimulating agents

Daisuke Katagiri, Fumihiko Hinoshita

Daisuke Katagiri, Division of Nephrology and Endocrinology, The University of Tokyo, Tokyo 162-8655, Japan

Fumihiko Hinoshita, Department of Nephrology, National Center for Global Health and Medicine, Tokyo 162-8655, Japan

Author contributions: Katagiri D and Hinoshita F contributed to this paper.

Correspondence to: Fumihiko Hinoshita, MD, PhD, Department of Nephrology, National Center for Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo 162-8655, Japan. fhinoshi@hosp.ncgm.go.jp

Telephone: +81-3-32027181 Fax: +81-3-32071038

Received: April 24, 2014
Revised: June 5, 2014
Accepted: July 17, 2014
Published online: November 24, 2014
Processing time: 208 Days and 19.5 Hours

Core Tip

Core tip: Renal anemia is a common clinical problem in patients with severe chronic kidney disease. To overcome the shortage of endogenous erythropoietin (EPO), administration of exogenous EPO is an effective treatment. The advent of recombinant human erythropoietin (rHu-EPO) products has dramatically changed the therapeutic strategy and has shown outstanding effectiveness in patients with renal anemia. Here we discuss the treatment of renal anemia and the adverse effects of rHu-EPO.