Renterghem KV, Rosette JL, Thijs H, Wisanto E, Achten R, Ory JP, Koeveringe GV. Alternative mechanisms for prostate-specific antigen elevation: A prospective analysis of 222 transurethral resections of prostate patients. World J Clin Urol 2014; 3(2): 144-151 [DOI: 10.5410/wjcu.v3.i2.144]
Corresponding Author of This Article
Koenraad van Renterghem, MD, PhD, Department of Urology, Jessa Hospital, Stadsomvaart 11, 3500 Hasselt, Belgium. koenraad.van.renterghem@ageingmaleclinic.be
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Prospective Study
Open-Access Policy of This Article
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World J Clin Urol. Jul 24, 2014; 3(2): 144-151 Published online Jul 24, 2014. doi: 10.5410/wjcu.v3.i2.144
Alternative mechanisms for prostate-specific antigen elevation: A prospective analysis of 222 transurethral resections of prostate patients
Koenraad van Renterghem, JJMCH de la Rosette, Herbert Thijs, Erika Wisanto, Ruth Achten, Jean-Paul Ory, Gommert van Koeveringe
Koenraad van Renterghem, Department of Urology, Jessa Hospital, 3500 Hasselt, Belgium
JJMCH de la Rosette, Department of Urology, Academic Hospital Amsterdam, 1105 AZ Amsterdam, The Netherlands
Herbert Thijs, Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, 3500 Hasselt, Belgium
Herbert Thijs, Interuniversity Institute for Biostatistics and Statistical Bioinformatics, KULeuven, 3000 Leuven, Belgium
Erika Wisanto, Ruth Achten, Department of Pathology, Jessa Hospital, 3500 Hasselt, Belgium
Jean-Paul Ory, Department of Anesthesiology, Jessa Hospital, 3500 Hasselt, Belgium
Gommert van Koeveringe, Department of Urology, University Hospital Maastricht, 6229 HX Maastricht, The Netherlands
Author contributions: van Renterghem K contributed to the set up of the research, was the main author of the manuscript and responsible for the surgery and determination of PSA levels, International Prostate Symptoms Score, prostate weight, post residual volume and pressure flow parameters; de la Rosette JJMCH, Ory JP and van Koeveringe G contributed to the scientific advice, revision of data and writing of the manuscript; Thijs H contributed to the statistical analysis and writing of the manuscript; Wisanto E and Achten R contributed to the histopathological analysis and writing of the manuscript.
Correspondence to: Koenraad van Renterghem, MD, PhD, Department of Urology, Jessa Hospital, Stadsomvaart 11, 3500 Hasselt, Belgium. koenraad.van.renterghem@ageingmaleclinic.be
Telephone: +32-11-308991 Fax: +32-11-309998
Received: December 18, 2013 Revised: February 14, 2014 Accepted: March 11, 2014 Published online: July 24, 2014 Processing time: 213 Days and 0.2 Hours
Core Tip
Core tip: The goal was to investigate the relationship between prostate-specific antigen (PSA) levels and (1) bladder outlet obstruction (BOO) and (2) the severity of prostate inflammation. We performed a prospective study on 222 consecutive patients undergoing transurethral resection of the prostate. Patients with proven urinary tract infection and/or known prostate cancer were excluded. PSA levels, International Prostate Symptoms Score, prostate weight, post residual volume and pressure flow parameters were determined. A histopathological assessment of the presence and severity of inflammation was also performed. In this study we showed a correlation between BOO (PdetQmax) and PSA (logarithmic). Furthermore, we demonstrated a weak correlation between PSA (logarithmic) and active as well as chronic prostatic inflammation.
