Brief Article
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World J Clin Urol. Jul 24, 2013; 2(2): 10-14
Published online Jul 24, 2013. doi: 10.5410/wjcu.v2.i2.10
Potential of metastin and metastin receptor as biomarkers for urological cancers
Sunao Shoji, Haruhiro Sato, Tetsuro Tomonaga, Hakushi Kim, Shuichi Soeda, Mayura Nakano, Toyoaki Uchida, Toshiro Terachi, Koichi Takeya
Sunao Shoji, Tetsuro Tomonaga, Hakushi Kim, Toyoaki Uchida, Department of Urology, Tokai University Hachioji Hospital, Hachioji, Tokyo 192-0032, Japan
Haruhiro Sato, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan
Shuichi Soeda, Department of Urology, Tokai University Oiso Hospital, Naka-gun, Kanagawa 259-0198, Japan
Mayura Nakano, Department of Urology, Numazu City Hospital, Numazu, Shizuoka 410-0302, Japan
Toshiro Terachi, Department of Urology, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan
Koichi Takeya, Department of Natural Products and Medical Chemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0355, Japan
Author contributions: Shoji S designed research and performed research; Shoji S, Sato H, Tomonaga T, Kim H, Soeda S, Nakano M, Uchida T, Terachi T and Takeya K analyzed data; Shoji S wrote the paper.
Correspondence to: Sunao Shoji, MD, PhD, Department of Urology, Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji, Tokyo 192-0032, Japan. sunashoj@mail.goo.ne.jp
Telephone: +81-42-6391111 Fax: +81-42-6391111
Received: April 15, 2013
Revised: May 31, 2013
Accepted: June 8, 2013
Published online: July 24, 2013
Processing time: 101 Days and 4.9 Hours
Core Tip

Core tip: Metastin and metastin receptor have attracted interest in the field of cancer because of their novelty and potential to inhibit cancer metastasis. Furthermore, they have potential as suitable molecular biomarkers for urological cancers. However, the results of all of the studies analyzed in this review were retrospectively obtained. Therefore, future studies of metastin and metastin receptor should undergo external validation to ensure consistency across different patient series, since individual institutional studies lack generalization.