Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Urol. Mar 18, 2025; 14(1): 104791
Published online Mar 18, 2025. doi: 10.5410/wjcu.v14.i1.104791
Diagnostic and therapeutic considerations for primary penal synovial sarcoma with specific MDM2 gene amplification: A case report
Chao-Hua Deng, Yuan Zhou, Jing Chen, Guo-Fu He, Qun-Shan Fu, Jiong-Ming Li, Guang Wang, Xiao-Dong Hu
Chao-Hua Deng, Yuan Zhou, Xiao-Dong Hu, Department of Urology, The Fourth Affiliated Hospital of Dali University, Chuxiong 675000, Yunnan Province, China
Jing Chen, Department of Nuclear Magnetic Resonance, The Fourth Affiliated Hospital of Dali University, Chuxiong 675000, Yunnan Province, China
Guo-Fu He, Department of Computed Tomography, The Fourth Affiliated Hospital of Dali University, Chuxiong 675000, Yunnan Province, China
Qun-Shan Fu, Department of Pathology, The Fourth Affiliated Hospital of Dali University, Chuxiong 675000, Yunnan Province, China
Jiong-Ming Li, Guang Wang, The Third Ward of Department of Urology, The Second Affiliated Hospital of Kunming Medical University, Kunming 675000, Yunnan Province, China
Co-first authors: Chao-Hua Deng and Yuan Zhou.
Author contributions: Deng CH and Zhou Y undertook the initial writing of the manuscript and were involved in subsequent revisions; Chen J conducted an analysis of the patient's magnetic resonance imaging data and furnished the corresponding images along with their captions; He GF carried out an analysis of the patient's CT data and provided the relevant images and accompanying captions; Fu QS analyzed the patient's pathological section data and supplied the appropriate images and captions; Li JM and Wang G offered professional guidance and valuable suggestions for the improvement of the article; Hu XD revised the initial draft of the paper and took charge of the submission process.
Supported by The Joint Special Project of Universities in Yunnan Province in 2022, No. 2022-ES-530101-207; and The Hospital-level Scientific Research Project of The Fourth Affiliated Hospital of Dali University, No. 2024YJ14.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Dong Hu, MD, Department of Urology, The Fourth Affiliated Hospital of Dali University, No. 318 Lucheng South Road, Chuxiong 675000, Yunnan Province, China. 2638522518@qq.com
Received: January 6, 2025
Revised: February 23, 2025
Accepted: March 8, 2025
Published online: March 18, 2025
Processing time: 74 Days and 23.8 Hours
Core Tip

Core Tip: Primary renal synovial sarcoma (PRSS) is rare, mostly with SYT-SSX gene fusion. This paper reports a case of PRSS with specific MDM2 gene amplification. The patient had metastasis soon after surgery and died rapidly, suggesting this type of PRSS has poor prognosis, high malignancy and rapid progression, which requires clinical vigilance.