Observational Study
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World J Clin Urol. Jul 24, 2014; 3(2): 139-143
Published online Jul 24, 2014. doi: 10.5410/wjcu.v3.i2.139
Bone markers predict survival in castration-resistant prostate cancer patients treated with docetaxel
Takumi Endo, Naoto Kamiya, Hiroyoshi Suzuki, Ryo Oka, Fang-Ching Lee, Takanobu Utsumi, Masashi Yano, Shuichi Kamijima, Koji Kawamura, Takashi Imamoto, Tomohiko Ichikawa
Takumi Endo, Naoto Kamiya, Hiroyoshi Suzuki, Ryo Oka, Fang-Ching Lee, Takanobu Utsumi, Masashi Yano, Shuichi Kamijima, Department of Urology, Toho University Sakura Medical Center, Sakura-shi, Chiba 285-8741, Japan
Koji Kawamura, Takashi Imamoto, Tomohiko Ichikawa, Department of Urology, Graduate School of Medicine, Chiba University, Chiba-shi, Chiba 260-8670, Japan
Author contributions: All authors equally contributed this study.
Supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan, No. 22591761, No. 23791792
Correspondence to: Naoto Kamiya, MD, Department of Urology, Toho University Sakura Medical Center, 564-1 Shimo-shizu, Sakura-shi, Chiba 285-8741, Japan. naoto.kamiya@med.toho-u.ac.jp
Telephone: +81-43-4628811 Fax: +81-43-4621700
Received: March 11, 2014
Revised: May 11, 2014
Accepted: June 18, 2014
Published online: July 24, 2014
Processing time: 130 Days and 6.4 Hours
Abstract

AIM: To investigate the relationship between clinicopathological features and bone turnover markers in castration-resistant prostate cancer (CRPC) patients treated with docetaxel.

METHODS: Thirty-three patients were enrolled in this study. Serum levels of carboxyterminal cross-linked telopeptide of type 1 collagen generated by metalloproteinases (1CTP) and alkaline phosphatase (ALP) were measured at the start of docetaxel chemotherapy. We examined the relationship between clinicopathological features and serum levels of 1CTP and ALP levels in CRPC patients treated with docetaxel.

RESULTS: For the total patient group, the mean ± standard deviation (SD) values for docetaxel chemotherapy dose, dose intensity, dosage interval, and number of cycles were 59.3 ± 10.6 mg/m2, 13.9 ± 5.2 mg/m2 per week, 4.7 ± 1.2 wk, and 11.2 ± 7.4, respectively. Fourteen patients died from prostate cancer. Patients were divided into two groups according to mean + SD of serum 1CTP (8.2 ng/mL) and ALP (538.2 IU/L) levels at the start of docetaxel chemotherapy. Patients with lower levels of serum 1CTP and ALP had significantly better survivals than those with higher serum levels (P < 0.05).

CONCLUSION: Serum levels of 1CTP and ALP are predictors of survival in patients with CRPC who are treated with docetaxel.

Keywords: Prostate cancer; Docetaxel chemotherapy; Carboxy-terminal pyridinoline cross-linked telopeptide parts of type-1 collagen; Alkaline phosphatase; Prognostic factor

Core tip: This study examined the relationship between clinicopathological features and serum levels of carboxy-terminal pyridinoline cross-linked telopeptide parts of type-1 collagen (1CTP) and alkaline phosphatase (ALP) in castration-resistant prostate cancer patients treated with docetaxel. Patients were divided into two groups according to mean + SD of serum 1CTP (8.2 ng/mL) and ALP (538.2 IU/L) levels at the start of docetaxel chemotherapy. Patients with lower levels of serum 1CTP and ALP had significantly better survivals than those with higher serum levels. Serum levels of 1CTP and ALP are predictors of survival in patients with CRPC who are treated with docetaxel.