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World J Clin Urol. Mar 24, 2014; 3(1): 31-37
Published online Mar 24, 2014. doi: 10.5410/wjcu.v3.i1.31
Systematic review of the non surgical management of Peyronie's disease
Paolo Verze, Davide Arcaniolo, Tommaso Cai, Marco Franco, Roberto La Rocca, Mario Acquaviva, Lorenzo Spirito, Aleksandre Bochorishvili, Vincenzo Mirone
Paolo Verze, Davide Arcaniolo, Tommaso Cai, Marco Franco, Roberto La Rocca, Mario Acquaviva, Lorenzo Spirito, Vincenzo Mirone, Department of Neuroscience, Reproductive Sciences and Odontostomatology, Urology Unit, University of Naples Federico II, 80131 Naples, Italy
Aleksandre Bochorishvili, National Centre of Urology, 00144 Tbilisi Georgia, Italy
Author contributions: Verze P, Arcaniolo D and Mirone V contributed to drafting manuscript; Verze P and Mirone V contributed to final review of the content; Cai T, Franco M, La Rocca R, Acquaviva M, Spirito L and Bochorishvili A contributed to selecting studies; Acquaviva M and Spirito L contributed to reference listing.
Correspondence to: Paolo Verze, MD, PhD, Department of Neuroscience, Reproductive Sciences and Odontostomatology, Urology Unit, University of Naples Federico II, Via S. Pansini, 80131 Naples, Italy. pverze@gmail.com
Telephone: +39-081-7462611 Fax: +39-081-7462611
Received: December 24, 2013
Revised: February 3, 2014
Accepted: February 16, 2014
Published online: March 24, 2014
Processing time: 91 Days and 4.8 Hours
Abstract

This systematic review shows the “Status quo” on medical treatment for Peyronie’s disease (PD). PD is a connective tissue disorder, characterised by the formation of a fibrotic lesion or plaque in the tunica albuginea, which leads to penile deformity. The aetiology of PD is unknown. Nowadays the most widely accepted hypothesis proposed by Gonzalez-Cadavid et al, is repetitive microvascular injury or trauma to the tunica albuginea. Physicians have proposed several medical alternatives for treatment of this disease with few effective results. Nevertheless, as of today nonsurgical options are currently available, and some of them are able to stabilize or even reduce deformity while improving pain relief and sexual function. A systematic literature search throughout the Medline database was carried out. The controlled vocabulary of the medical subject headings database employs the specific term “penile induratio” for PD. A total of 50 articles on PD were found. Studies were selected based on clinical relevance. The recommended standard of care for PD involves an initial treatment in the acute phase. Several non-operative treatment options have been used. Unfortunately no further substantial, quality evidence on the use of medical therapy currently exits. There is, however, an increasingly enhanced interest in this disorder and basic scientific and clinical research will eventually lead to a more effective methodology to study the disease.

Keywords: Peyronie’s disease; Non surgical; Dupuytren; Extracorporeal shockwave therapy

Core tip: Ince the first medical publication on Peyronie’s Disease, physicians have proposed several medical alternatives for treatment of this disease. As of today nonsurgical options are currently available. A consistent number of non-surgical treatment options that offer some benefit with respect to disease stabilization, alleviation, as well as reduction of deformity and improved sexual function are available including oral treatment with potassium para-aminobenzoate, intralesional treatment with interferon, iontophoresis with verapamil 5 mg and dexamethasone 8 mg and extracorporeal shock-wave treatment.