Copyright
©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Aug 30, 2018; 7(3): 83-88
Published online Aug 30, 2018. doi: 10.5409/wjcp.v7.i3.83
Published online Aug 30, 2018. doi: 10.5409/wjcp.v7.i3.83
Clinical features of acute kidney injury in patients with Kawasaki disease
Toru Watanabe, Department of Pediatrics, Niigata City General Hospital, Niigata City 950-1197, Japan
Author contributions: Watanabe T solely contributed to this paper.
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Toru Watanabe, MD, PhD, Doctor, Department of Pediatrics, Niigata City General Hospital, 463-7 Shumoku, Chuo-ku, Niigata City, 950-1197, Japan. twata@hosp.niigata.niigata.jp
Telephone: +81-25-2815151 Fax: +81-25-2815169
Received: June 19, 2018
Peer-review started: June 20, 2018
First decision: June 19, 2018
Revised: August 1, 2018
Accepted: August 6, 2018
Article in press: August 7, 2018
Published online: August 30, 2018
Processing time: 72 Days and 4.1 Hours
Peer-review started: June 20, 2018
First decision: June 19, 2018
Revised: August 1, 2018
Accepted: August 6, 2018
Article in press: August 7, 2018
Published online: August 30, 2018
Processing time: 72 Days and 4.1 Hours
Core Tip
Core tip: Acute kidney injury (AKI) has rarely been reported in patients with Kawasaki disease (KD). We review the clinical characteristics of AKI in patients with KD and show that AKI is caused by a number of pathologic changes induced by KD. Patients with KD and AKI had good outcomes, despite the developed of multiple organ dysfunction syndrome. The possible mechanisms underlying the development of AKI in KD include T-cell-mediated immunologic abnormalities, renal and glomerular endothelial injury resulted from vasculitis, immune complex-mediated kidney injury, and capillary leak and the increased release of cytokines with myocardial dysfunction.