Effects of carob-bean gum thickened formulas on infants’ reflux and tolerance indices
Miglena Georgieva, Yannis Manios, Niya Rasheva, Ruzha Pancheva, Elena Dimitrova, Anne Schaafsma
Miglena Georgieva, Niya Rasheva, Elena Dimitrova, Second Pediatric Clinic, University Hospital ”St. Marine”, 9000 Varna, Bulgaria
Yannis Manios, Department of Nutrition and Dietetics, Harokopio University of Athens, 17671 Kallithea, Athens, Greece
Ruzha Pancheva, Department of Hygiene, Medical University, 9000 Varna, Bulgaria
Anne Schaafsma, Friesland Campina, Stationsplein 4, 3800 BN Amersfoort, the Netherlands
Author contributions: Georgieva M and Schaafsma A conceived and designed the research; Georgieva M, Rasheva N, Pancheva R and Dimitrova E conducted the research; Georgieva M, Manios Y and Schaafsma A conducted the literature review; Manios Y lead the statistical analyses with the contribution and input from all authors; all authors took part in writing and revising the manuscript.
Supported by A research grant from FrieslandCampina.
Institutional review board statement: The study was reviewed and approved by the Medical Ethical Committee of the “St. Marina” University Hospital of Varna (Ethical approval No. 13/03.28.2013) and was implemented in accordance to the signed protocol and the rules for good clinical practice.
Clinical trial registration statement: The study is registered at http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4334. The registration identification number is NTR4334.
Informed consent statement: Written informed consent was obtained from the parents of all infants that were found to be eligible to be included in the study, prior to study enrollment.
Conflict-of-interest statement: Anne Schaafsma works for Friesland Campina. None of the other authors has any conflicts of interest to declare.
Data sharing statement: No further data is available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Miglena Georgieva, MD, PhD, Associate Professor, Second Pediatric Clinic, University Hospital ”St. Marine”, 1 Christo Smirnenski Avenue, 9000 Varna, Bulgaria.
mgeorgieva7@yahoo.com
Telephone: +359-89-9074268 Fax: +359-52-302874
Received: July 14, 2015
Peer-review started: July 17, 2015
First decision: October 21, 2015
Revised: November 4, 2015
Accepted: November 10, 2015
Article in press: November 10, 2015
Published online: February 8, 2016
Processing time: 197 Days and 17.6 Hours
