Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Sep 9, 2025; 14(3): 103873
Published online Sep 9, 2025. doi: 10.5409/wjcp.v14.i3.103873
Comparative analysis on the efficacy of antenatal corticosteroids in preterm newborns in a Kazakhstani Tertiary Care Hospital setting
Saltanat Sairankyzy, Ingkar Kinayatova, Diana Amangeldi, Ainura Zhumatova, Nishankul Bozhbanbayeva, Ainash Ismailova, Nazgul Akhtayeva, Olga An
Saltanat Sairankyzy, Nishankul Bozhbanbayeva, Department of Neonatology, S.D. Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan
Ingkar Kinayatova, Diana Amangeldi, Ainura Zhumatova, General Medicine, S.D. Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan
Ainash Ismailova, Neonatal Intensive Care Unit, Enbekshikazakh Multidisciplinary Central District Hospital, Issyk 040400, Enbekshikazakh district of Almaty region, Kazakhstan
Nazgul Akhtayeva, Department of Biostatistics and Fundamentals of Scientific Research, S.D.Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan
Olga An, Department of Propaedeutics of Childhood Diseases, S.D. Asfendiyarov Kazakh National Medical University, Almaty 050012, Kazakhstan
Co-corresponding authors: Saltanat Sairankyzy and Ingkar Kinayatova.
Author contributions: Sairankyzy S conceptualized the research idea, developed the study design, secured funding, and supervised the entire research process from initiation to finalization. Kinayatova I was involved in material collection, data analysis, interpretation of results and was responsible for formatting and submitting the final version of the article. Both authors have made essential contributions to the submission of the manuscript, and are therefore designated as co-corresponding authors of the paper. Amangeldi D and Zhumatova A actively participated in data collection, conducted additional analyses, created tables and figures, interpreted the findings, and contributed to the preparation of the manuscript. Bozhbanbayeva N co-developed the study design and was involved in securing research funding and overall conceptual contributions. Akhtayeva N performed statistical data processing, including biostatistical analysis and result interpretation. Ismailova A assisted in working with patient data, including collection and detailed review of medical histories. An O contributed to the data collection and was also involved in editing and refining the manuscript text.
Supported by Non-profit Joint Stock Company “S.D. Asfendiyarov Kazakh National Medical University”, Almaty, Kazakhstan.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Kazakhstan Medical University “School of Public Health” (Approval No: IRB - A171, dated September 18, 2024).
Informed consent statement: Since this research was retrospective in nature, individual informed consent was not required. However, all necessary ethical considerations, including data confidentiality and compliance with institutional and international ethical guidelines, were strictly followed.
Conflict-of-interest statement: All authors declare no conflicts of interest.
STROBE statement: This manuscript contains all the items according to the STROBE checklist: title, abstract, relevance, aim, methods and materials, research results, discussion and conclusion.
Data sharing statement: The data presented in this study are available on request from the corresponding author. The data are not publicly available due to patients’ privacy restrictions.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Saltanat Sairankyzy, PhD, Associate Professor, Department of Neonatology, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Tole bi Str. 94, Almaty 050012, Kazakhstan. salta3105@mail.ru
Received: December 11, 2024
Revised: March 22, 2025
Accepted: April 21, 2025
Published online: September 9, 2025
Processing time: 187 Days and 19.2 Hours
Core Tip

Core Tip: This retrospective cohort study was aimed to evaluate the effect of antenatal steroid prophylaxis (ASP) on the general condition of preterm newborns. It demonstrates collected clinical data from January 2022 to February 2024 in Kazakhstan, Almaty region. 152 premature newborns with gestational ages between 24 and 34 weeks were analyzed depending on the completeness of ASP among them. Results show effect of ASP in prevention of respiratory distress syndrome and incidences of comorbidities related to respiratory, cardiovascular and digestive systems. In conclusion, findings suggest that ASP significantly improves neonatal outcomes, particularly in reducing birth asphyxia, primary resuscitation measures, need for lung ventilation including mechanical ventilation and nasal continuous positive airway pressure, and re-intubation cases.