Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Sep 9, 2025; 14(3): 103732
Published online Sep 9, 2025. doi: 10.5409/wjcp.v14.i3.103732
Outcomes and adverse events following intra-arterial chemotherapy for retinoblastoma: A single center study in South India
Abhishek Das, Kothapally Saiteja, Parag K Shah, Subramaniam Prema, Venkatapathy Narendran
Abhishek Das, Parag K Shah, Subramaniam Prema, Venkatapathy Narendran, Department of Pediatric Retina and Ocular Oncology, Postgraduate Institute of Ophthalmology, Aravind Eye Hospital, Coimbatore 641014, Tamil Nādu, India
Kothapally Saiteja, Department of General Ophthalmology, Aravind Eye Hospital, Coimbatore 641014, Tamil Nādu, India
Author contributions: Das A and Shah PK designed the study; Das A and Prema S conducted the study; Saiteja K analyzed the data and wrote the paper; Narendran V supervised the study; All authors read and approved the final version of the manuscript to be published.
Institutional review board statement: This study was reviewed and approved by the Institutional Ethics Committee of PSG Institute of Medical Sciences, Coimbatore, India.
Informed consent statement: Not required as it was a retrospective study.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at drshahpk2002@yahoo.com
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Parag K Shah, Professor, Department of Pediatric Retina and Ocular Oncology, Postgraduate Institute of Ophthalmology, Aravind Eye Hospital, Avinashi Road, Coimbatore 641014, Tamil Nādu, India. drshahpk2002@yahoo.com
Received: December 3, 2024
Revised: March 1, 2025
Accepted: March 12, 2025
Published online: September 9, 2025
Processing time: 199 Days and 8 Hours
Core Tip

Core Tip: Intra-arterial chemotherapy has become a first-line standard treatment for retinoblastoma. However, studies describing its adverse events are sparse, especially from the developing world. Our study described the challenges, treatment outcomes, and complications of selective intra-arterial chemotherapy for retinoblastoma in an Indian cohort. Our retrospective study showed that intra-arterial chemotherapy was effective in low resource settings with minimal adverse events.