Understanding antituberculosis drug-induced hepatotoxicity: Risk factors and effective management strategies in the pediatric population

doi:10.5409/wjcp.v14.i2.101875

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World Journal of Clinical Pediatrics

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2219-2808

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World J Clin Pediatr. Jun 9, 2025; 14(2): 101875
Published online Jun 9, 2025. doi: 10.5409/wjcp.v14.i2.101875

Understanding antituberculosis drug-induced hepatotoxicity: Risk factors and effective management strategies in the pediatric population

Pooja Semwal, Manjit Kaur Saini, Moinak Sen Sarma

Pooja Semwal, Department of Pediatrics, Hind Institute of Medical Sciences, Lucknow, Lucknow 261303, Uttar Pradesh, India

Manjit Kaur Saini, Moinak Sen Sarma, Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India

Author contributions: Semwal P and Saini MK drafted the manuscript; and all authors reviewed the manuscript; Sarma MS approved the final version of the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Moinak Sen Sarma, DM, Additional Professor, Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India. moinaksen@gmail.com

Received: September 29, 2024
Revised: January 6, 2025
Accepted: January 23, 2025
Published online: June 9, 2025
Processing time: 169 Days and 20.4 Hours

Core Tip

Core Tip: Antituberculosis therapy (ATT) causes hepatotoxicity as a major side effect. The withdrawal of ATT and modification of ATT remains the cornerstone for immediate management of ATT induced hepatotoxicity.