Choed-Amphai C, Kusontammarat P, Chanthong S, Arkarattanakul N, Rodchaprom P, Sathitsamitphong L, Natesirinilkul R, Charoenkwan P. Clinical course and management of hypertriglyceridemia thalassemia syndrome: A case-based systematic review. World J Clin Pediatr 2025; 14(2): 101543 [DOI: 10.5409/wjcp.v14.i2.101543]
Corresponding Author of This Article
Chane Choed-Amphai, MD, Assistant Professor, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, No. 110 Intawarorot Road, Sriphum, Muang, Chiang Mai 50200, Thailand. chane.c@cmu.ac.th
Research Domain of This Article
Hematology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Chane Choed-Amphai, Pattranan Kusontammarat, Supapitch Chanthong, Nattawan Arkarattanakul, Lalita Sathitsamitphong, Rungrote Natesirinilkul, Pimlak Charoenkwan, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Poonyapon Rodchaprom, Department of Pediatrics, Fang Hospital, Chiang Mai 50110, Thailand
Pimlak Charoenkwan, Thalassemia and Hematology Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Co-first authors: Chane Choed-Amphai and Pattranan Kusontammarat.
Co-corresponding authors: Chane Choed-Amphai and Supapitch Chanthong.
Author contributions: Choed-Amphai C and Kusontammarat P drafted the manuscript, they contributed equally to this article, they are the co-first authors of this manuscript; Choed-Amphai C, Kusontammarat P, Chanthong S, Arkarattanakul N, Rodchaprom P, Sathitsamitphong L, Natesirinilkul R and Charoenkwan P participated in patient management and data collection; Choed-Amphai C, Chanthong S, Arkarattanakul N contributed to the systematic review; Choed-Amphai C and Chanthong S contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors contributed to the article and approved the submitted version.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chane Choed-Amphai, MD, Assistant Professor, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, No. 110 Intawarorot Road, Sriphum, Muang, Chiang Mai 50200, Thailand. chane.c@cmu.ac.th
Received: September 18, 2024 Revised: February 21, 2025 Accepted: March 5, 2025 Published online: June 9, 2025 Processing time: 180 Days and 18.3 Hours
Core Tip
Core Tip: Secondary hypertriglyceridemia due to thalassemia should be considered in infants and young children who present with profound anemia and milky serum. Hemoglobin analysis and lipid profiling should be performed on both the patient and the parents to confirm the diagnosis of thalassemia and to rule out primary hypertriglyceridemia in the family. Management of patients with hypertriglyceridemia thalassemia syndrome using blood transfusions according to thalassemia guidelines has provided good outcomes. Although no hypertriglyceridemia-related complications have been observed in this review, regular monitoring of lipid profiles and potential complications - including pancreatitis, atherosclerosis, and non-alcoholic fatty liver disease - is warranted.
