Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Jun 9, 2025; 14(2): 100336
Published online Jun 9, 2025. doi: 10.5409/wjcp.v14.i2.100336
Uveitis associated with juvenile idiopathic arthritis and chronic idiopathic uveitis in children: A retrospective cohort study
Alexandr Alexandrovich Yakovlev, Ekaterina Vladimirovna Gaidar, Lyubov Sergeevna Sorokina, Tatiana Nikolaevna Nikitina, Olga Valerievna Kalashnikova, Mikhail Mikhailovich Kostik
Alexandr Alexandrovich Yakovlev, Ekaterina Vladimirovna Gaidar, Lyubov Sergeevna Sorokina, Olga Valerievna Kalashnikova, Mikhail Mikhailovich Kostik, Hospital Pediatry, Saint-Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia
Tatiana Nikolaevna Nikitina, Department of Ophthalmology, Saint-Petersburg State Pediatric Medical University, Saint Petersburg 194100, Russia
Author contributions: Yakovlev AA contributed to the formal analysis; Yakovlev AA and Kostik MM contributed to conceptualization, writing, the original draft preparation, reviewing, and editing; Gaidar EV and Kostik MM contributed to the methodology; Sorokina LS and Nikitina TN contributed to the validation; Nikitina TN, Gaidar EV, and Sorokina LS contributed to the investigation and visualization; Kalashnikova OV contributed to software, resources, and data curation; Kostik MM contributed to supervision and project administration; All authors read and agreed to the published version of the manuscript.
Institutional review board statement: The protocol of the study was approved by the local Ethical Committee of Saint Petersburg State Pediatric Medical University (No. 31/14 from 18.10.2023).
Informed consent statement: Informed consent was obtained from all subjects involved in the study.
Conflict-of-interest statement: The authors declare no conflicts of interest.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mikhail Mikhailovich Kostik, MD, PhD, Professor, Hospital Pediatry, Saint-Petersburg State Pediatric Medical University, Lytovskaya 2, Saint-Petersburg 194100, Russia. kost-mikhail@yandex.ru
Received: August 14, 2024
Revised: January 26, 2025
Accepted: February 17, 2025
Published online: June 9, 2025
Processing time: 215 Days and 14.3 Hours
Core Tip

Core Tip: It has been observed that the human leukocyte antigen-B27 allele behaves differently depending on the age of the individual. In individuals with human leukocyte antigen-B27 positivity over the age of seven, there is a significantly increased likelihood of developing acute uveitis compared to those under the age of seven. Despite this, systemic therapy appears to be equally effective in both groups albeit with delayed administration in children with chronic idiopathic uveitis.