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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Sep 9, 2024; 13(3): 98468
Published online Sep 9, 2024. doi: 10.5409/wjcp.v13.i3.98468
Published online Sep 9, 2024. doi: 10.5409/wjcp.v13.i3.98468
Decoding the genetic landscape of autism: A comprehensive review
Mohammed Al-Beltagi, Department of Pediatric, Faculty of Medicine, Tanta University, Alghrabia, Tanta 31511, Egypt
Mohammed Al-Beltagi, Department of Pediatric, University Medical Center, King Abdulla Medical City, Arabian Gulf University, Manama 26671, Bahrain
Nermin Kamal Saeed, Medical Microbiology Section, Department of Pathology, Salmaniya Medical Complex, Ministry of Health, Kingdom of Bahrain, Manama 12, Bahrain
Nermin Kamal Saeed, Medical Microbiology Section, Department of Pathology, Irish Royal College of Surgeon, Muharraq, Busaiteen 15503, Bahrain
Adel Salah Bediwy, Department of Pulmonology, Faculty of Medicine, Tanta University, Alghrabia, Tanta 31527, Egypt
Adel Salah Bediwy, Department of Pulmonology, University Medical Center, King Abdulla Medical City, Arabian Gulf University, Manama 26671, Bahrain
Eman A Bediwy, Internal Medicine, Faculty of Medicine, Tanta University, Algharbia, Tanta 31527, Egypt
Reem Elbeltagi, Department of Medicine, The Royal College of Surgeons in Ireland-Bahrain, Muharraq, Busiateen 15503, Bahrain
Co-first authors: Mohammed Al-Beltagi and Nermin Kamal Saeed.
Author contributions: Al-Biltagi M coordinated the project, contributed to the design, supervised the literature search, and ensured data integrity; Saeed NK was involved in the methodology, literature screening, data extraction, and manuscript writing; Bediwy AS participated in the literature search, data extraction, preliminary analyses, and manuscript drafting; Bediwy EA oversaw technical aspects, quality control, and statistical analysis and contributed to the manuscript, particularly in the analysis sections; Elbeltagi R addressed ethical considerations, contributed to the literature search and data extraction, and provided insights during data synthesis. All authors critically revised the manuscript and approved the final version, agreeing to be accountable for all aspects of the work. Al-Biltagi M and Saeed NK contributed equally to this work as co-first authors.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest regarding the publication of this manuscript.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohammed Al-Beltagi, MBChB, MD, PhD, Academic Editor, Chairman, Full Professor, Research Scientist, Department of Pediatric, Faculty of Medicine, Tanta University, Al-Bahr Street, The Medical Complex, Alghrabia, Tanta 31511, Egypt.
Received: June 26, 2024
Revised: July 29, 2024
Accepted: August 1, 2024
Published online: September 9, 2024
Processing time: 64 Days and 6.5 Hours
Revised: July 29, 2024
Accepted: August 1, 2024
Published online: September 9, 2024
Processing time: 64 Days and 6.5 Hours
Core Tip
Core Tip: This review synthesizes current knowledge on the genetic and epigenetic factors contributing to autism spectrum disorder (ASD). It highlights the complexity of ASD's genetic architecture and the role of epigenetic mechanisms such as DNA methylation and non-coding RNAs in disease pathogenesis. Emerging technologies like Clustered Regularly Interspaced Short Palindromic Repeats-Cas9 and advanced bioinformatics are pivotal for advancing our understanding of ASD. Collaborative research efforts are crucial for integrating diverse disciplines and international data, aiming to translate genetic insights into personalized therapies. Addressing unresolved questions and ethical considerations will be essential for maximizing the clinical utility of genetic discoveries in improving outcomes for individuals with ASD.