Case Control Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Pediatr. Mar 9, 2024; 13(1): 88645
Published online Mar 9, 2024. doi: 10.5409/wjcp.v13.i1.88645
Salivary C-reactive protein and mean platelet volume as possible diagnostic markers for late-onset neonatal pneumonia
Wafaa Ahmed Metwali‎, Abdelrahman Mohamed Elmashad, Sahar Mohey Eldin Hazzaa, Mohammed Al-Beltagi, Mohamed Basiony Hamza‎
Wafaa Ahmed Metwali‎, Abdelrahman Mohamed Elmashad, Mohammed Al-Beltagi, Mohamed Basiony Hamza‎, Department of Pediatric, Faculty of Medicine, Tanta University, Tanta 31511, Algahrbia, Egypt
Sahar Mohey Eldin Hazzaa, Department of Clinical Pathology, Faculty of Medicine, ‎Tanta University‎, Tanta ‎31511‎, Algahrbia, Egypt
Mohammed Al-Beltagi, Department of Pediatric, University Medical Center, Dr. Suliaman Al Habib Medical Group, Manama 26671, Manama, Bahrain
Mohammed Al-Beltagi, Department of Pediatric, University Medical Center, King Abdulla Medical City, Arabian Gulf University, Manama 26671, Manama, Bahrain
Author contributions: El-Mashad MA and Hamza MB provided the research idea and initiated the study design; Metwali WA and El-Mashad MA collected the patients and their information; Hamza M and El-Mashad MA were responsible for statistical analysis; Metwali WA and Hazzaa HM were responsible for the technical part of the study; Also, they performed data analysis; Al-Biltagi M analyzed the data and wrote the final manuscript; all authors revised and agreed on the final version of the manuscript.
Institutional review board statement: We performed the study according to the latest version of Helsinki's Declaration. The Institutional Ethical and Research Review Board of the Faculty of Medicine, Tanta University, approved the study.
Informed consent statement: All parents, guardians, or next of kin signed informed consent for the minors to participate in this study.
Conflict-of-interest statement: All the authors declare that they have no potential nor real conflicts to disclose.
Data sharing statement: Data are available upon reasonable request.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohammed Al-Beltagi, MBChB, MD, PhD, Academic Editor, Chairman, Professor, Research Scientist, Department of Pediatric, Faculty of Medicine, Tanta University, Al-Bahr Street, Tanta ‎31511‎, Alghrabia, Egypt. mbelrem@hotmail.com
Received: October 3, 2023
Peer-review started: October 3, 2023
First decision: November 2, 2023
Revised: November 3, 2023
Accepted: December 11, 2023
Article in press: December 11, 2023
Published online: March 9, 2024
Processing time: 155 Days and 16 Hours
Core Tip

Core Tip: This prospective study explores the potential of salivary C-reactive protein (CRP) (sCRP) and mean platelet volume (MPV) as diagnostic markers for late-onset neonatal pneumonia (LONP). Analyzing 80 neonates, significant differences in serum CRP levels, MPV, and the serum CRP/MPV ratio were observed between LONP cases and healthy controls. MPV demonstrated strong discriminatory ability with high sensitivity and specificity at a cutoff value of > 8.8. sCRP displayed notable predictive value for serum CRP levels. These findings highlight the diagnostic potential of salivary and serum biomarkers in identifying and predicting LONP among neonates.