Seronegative autoimmune hepatitis in childhood

doi:10.5409/wjcp.v12.i3.77

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World Journal of Clinical Pediatrics

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2219-2808

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Pediatr. Jun 9, 2023; 12(3): 77-85
Published online Jun 9, 2023. doi: 10.5409/wjcp.v12.i3.77

Seronegative autoimmune hepatitis in childhood

Ali Islek, Gokhan Tumgor

Ali Islek, Gokhan Tumgor, Department of Pediatric Gastroenterology, Cukurova University School of Medicine, Adana 01320, Turkey

Author contributions: Islek A substantially contributed to the conception and design of the paper and the acquisition, analysis and interpretation of the data; Islek A and Tumgor G drafted the article and made critical revisions related to the intellectual content of the manuscript and approved the final version of the article to be published.

Conflict-of-interest statement: There was no conflict of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ali Islek, MD, Associate Professor, Department of Pediatric Gastroenterology, Cukurova University School of Medicine, Sarıcam, Adana 01320, Turkey. islekali@hotmail.com

Received: January 28, 2023
Peer-review started: January 28, 2023
First decision: April 2, 2023
Revised: April 26, 2023
Accepted: May 8, 2023
Article in press: May 8, 2023
Published online: June 9, 2023
Processing time: 130 Days and 15.2 Hours

Core Tip

Core Tip: Seronegative autoimmune hepatitis is a diagnostic dilemma. The absence of autoantibodies and hypergammaglobulinemia which is not uncommon in seronegative autoimmune hepatitis complicates the diagnosis. Seronegative autoimmune hepatitis often presents with acute hepatitis, and its treatment and prognosis similar to seropositive autoimmune hepatitis. This review discusses whether seronegativity is only a matter of laboratory issue or if it implies an entity with different pathogenesis, clinical features, treatment algorithms, and prognosis.