Rigterink T, Appleton L, Day AS. Vitamin D therapy in children with inflammatory bowel disease: A systematic review. World J Clin Pediatr 2019; 8(1): 1-14 [PMID: 30697514 DOI: 10.5409/wjcp.v8.i1.1]
Corresponding Author of This Article
Andrew S Day, MB, ChB, MD, Professor, Department of Paediatrics, University of Otago Christchurch, Riccarton Avenue, Christchurch 8041, New Zealand. andrew.day@otago.ac.nz
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Pediatr. Jan 22, 2019; 8(1): 1-14 Published online Jan 22, 2019. doi: 10.5409/wjcp.v8.i1.1
Vitamin D therapy in children with inflammatory bowel disease: A systematic review
Tarah Rigterink, Laura Appleton, Andrew S Day
Tarah Rigterink, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, the Netherlands
Tarah Rigterink, Laura Appleton, Andrew S Day, Department of Paediatrics, University of Otago Christchurch, Christchurch 8041, New Zealand
Author contributions: All authors contributed equally to the work; Day AS conceptualised and designed the review together with Rigterink T; Rigterink T and Day AS carried out the analysis; Rigterink T drafted the initial manuscript; all authors reviewed and approved the final manuscript as submitted.
Conflict-of-interest statement: All authors have no conflicts of interest to report.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Andrew S Day, MB, ChB, MD, Professor, Department of Paediatrics, University of Otago Christchurch, Riccarton Avenue, Christchurch 8041, New Zealand. andrew.day@otago.ac.nz
Received: October 8, 2018 Peer-review started: October 8, 2018 First decision: November 7, 2018 Revised: December 31, 2018 Accepted: January 10, 2019 Article in press: January 10, 2019 Published online: January 22, 2019 Processing time: 106 Days and 13.7 Hours
ARTICLE HIGHLIGHTS
Research background
Vitamin D deficiency is commonly seen in children diagnosed with inflammatory bowel disease (IBD). While vitamin D is important for bone health, inadequate levels may also influence the course of disease.
Research motivation
To date, however, the optimal manner to correct and maintain adequate vitamin D levels in children with IBD have not been established.
Research objectives
The principal objective of this work was to systematically review the published literature focusing on vitamin D therapy in children with IBD. The further objective was to highlight opportunities for future work to augment and enhance the current understanding in this field.
Research methods
The published literature was reviewed systematically for publications that had focused on vitamin D therapy in children with IBD. The available data was then reviewed in detail.
Research conclusions
Ten published articles were identified and reviewed in detail. These reports included very different study designs with varied treatment regimens. Overall, there was no clear optimal regimen or approach that consistently corrected vitamin D deficiency and maintained levels over time.
Research perspectives
Vitamin D sufficiency is an important aspect of managing children with IBD. The available published literature does not provide a clear approach to the management of deficiency of vitamin D in this setting. Various aspects likely influence the response to vitamin D therapy: these are important factors that need to be taken into account in considering future work in this area.
