Yusuf SO, Chen P. Clinical characteristics of community-acquired pneumonia in children caused by mycoplasma pneumoniae with or without myocardial damage: A single-center retrospective study. World J Clin Pediatr 2023; 12(3): 115-124 [PMID: 37342450 DOI: 10.5409/wjcp.v12.i3.115]
Corresponding Author of This Article
Peng Chen, Doctor, Chief Physician, Department of Pediatrics, The Second Hospital of Jilin University, Yatai Street, Changchun 130041, Jilin Province, China. c_p@jlu.edu.cn
Research Domain of This Article
Pediatrics
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Pediatr. Jun 9, 2023; 12(3): 115-124 Published online Jun 9, 2023. doi: 10.5409/wjcp.v12.i3.115
Clinical characteristics of community-acquired pneumonia in children caused by mycoplasma pneumoniae with or without myocardial damage: A single-center retrospective study
Shukri Omar Yusuf, Peng Chen
Shukri Omar Yusuf, Peng Chen, Department of Pediatrics, The Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
Author contributions: Yusuf SO conducted data collection, analysis, and manuscript drafting; Chen P conceived the study and supervised the entire study process; All authors read and approved the final manuscript.
Institutional review board statement: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board of The Second Hospital of Jilin University (In 2022, research review No. 073). Parents of all eligible children gave their informed consent for inclusion before they were admitted to the hospital. The confidentiality of the patients was ensured throughout the study.
Informed consent statement: This study consists of two parts: (1) We collected children’s medical history, diagnosis and supplementary examination in the inpatients department through the hospital computer; and (2) the results of this study may provide information for future clinical activities. At the same time, we will keep the children’s information and privacy strictly confidential. We promise to use it only for this study. Without permission, we will not disclose this information to third parties. We make every effort to protect the privacy of the personal medical data. We will not use any patients name or patients ID.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Data sharing statement: No additional data is available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Peng Chen, Doctor, Chief Physician, Department of Pediatrics, The Second Hospital of Jilin University, Yatai Street, Changchun 130041, Jilin Province, China. c_p@jlu.edu.cn
Received: December 3, 2022 Peer-review started: December 3, 2022 First decision: February 21, 2023 Revised: March 8, 2023 Accepted: March 30, 2023 Article in press: March 30, 2023 Published online: June 9, 2023 Processing time: 186 Days and 19.3 Hours
ARTICLE HIGHLIGHTS
Research background
Community-acquired pneumonia (CAP) is a significant cause of inpatient hospitalization and mortality in children.
Research motivation
This is crucial for pediatricians as it would enable us to make a quick diagnosis and consequently prompt treatment in case of severe mycoplasma pneumoniae pneumonia (MPP).
Research objectives
Our study highlighted which clinical parameters should be focused on to differentiate between mild and severe MPP.
Research methods
We identified children between 2 mo and 16 years of age with clinical and radiological findings consistent with CAP.
Research results
We found that the duration of fever and cough was longer in the severe MPP group than in the mild MPP group. Similarly, the high sensitivity C-reactive protein levels, procalcitonin, alanine transaminase, aspartate aminotransferase, and lactate dehydrogenase were significantly higher in the severe MPP cohort than in the mild MPP group. Paradoxically, the neutrophil count was significantly higher in the mild MPP group than in the severe MPP group.
Research conclusions
The incidence of myocardial damage was significantly higher in the severe MPP group than in mild MPP cases.
Research perspectives
It is unknown whether there is a causal link between severe MPP and myocardial damage; therefore, to ascertain this hypothesis, future research is recommended.
