Sherief LM, Goneim E, Kamal NM, Ibraheim A, Alsofiani F, Alawur A. Acute lymphoblastic leukemia in a β-thalassemia intermedia child: A case report. World J Clin Pediatr 2020; 9(1): 1-6 [PMID: 32844089 DOI: 10.5409/wjcp.v9.i1.1]
Corresponding Author of This Article
Naglaa M Kamal, MD, Full Professor, Department of Pediatrics and Pediatric Hepatology, Faculty of Medicine, Cairo University, Kasralainy, Cairo 21121, Egypt. nagla.kamal@kasralainy.edu.eg
Research Domain of This Article
Pediatrics
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Pediatr. Jul 14, 2020; 9(1): 1-6 Published online Jul 14, 2020. doi: 10.5409/wjcp.v9.i1.1
Acute lymphoblastic leukemia in a β-thalassemia intermedia child: A case report
Laila M Sherief, Esmael Goneim, Naglaa M Kamal, Amr Ibraheim, Fuad Alsofiani, Abdulraouf Alawur
Laila M Sherief, Department of Pediatric Hematology and Oncology, Faculty of Medicine, Zagazig University, Zagazig 44511, Egypt
Laila M Sherief, Amr Ibraheim, Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig 44511, Egypt
Esmael Goneim, Department of Pediatric Oncology, Tanta Cancer Institute, Tanta 00202, Egypt
Naglaa M Kamal, Department of Pediatrics and Pediatric Hepatology, Faculty of Medicine, Cairo University, Cairo 21121, Egypt
Naglaa M Kamal, Fuad Alsofiani, Department of Pediatrics, Alhada Armed Forces Hospital, Taif 00966, Saudi Arabia
Author contributions: Sherief LM was involved in conceptualization, data curation, investigation, project administration, supervision, validation, visualization, writing review and editing; Goneim I and Ibraheim A performed data curation; Kamal NM was involved in literature review, writing-original draft, writing review and editing; Alsofiani F and Alawur A performed literature review and wrote the original draft; All authors read and approved the final manuscript.
Informed consent statement: Written informed consent in the patient’s native language was obtained from her father.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Naglaa M Kamal, MD, Full Professor, Department of Pediatrics and Pediatric Hepatology, Faculty of Medicine, Cairo University, Kasralainy, Cairo 21121, Egypt. nagla.kamal@kasralainy.edu.eg
Received: January 17, 2020 Peer-review started: January 17, 2020 First decision: April 18, 2020 Revised: May 9, 2020 Accepted: June 10, 2020 Article in press: June 10, 2020 Published online: July 14, 2020 Processing time: 202 Days and 12.4 Hours
Abstract
BACKGROUND
β-thalassemia intermedia (βTI) is one of the hemoglobinopathies. It constitutes 10% of β-thalassemia cases and is associated with better quality of life than β-thalassemia major (βTM).
CASE SUMMARY
We recently reported the first case of acute lymphoblastic leukemia (ALL) from Egypt in a child with βTM, and we herein report the first case of ALL from Egypt in a child with βTI. In this report, literature was reviewed for cases of malignancies associated with βTI and the possible factors underling the relationship between the two entities.
CONCLUSIO
We stress that physicians should have a high index of suspicion of malignancies in thalassemia patients if they present with any suggestive symptoms or signs.
Core Tip: Cases of malignancies in patients of β-thalassemia major have been reported. However, rare cases have been reported for malignancies in patients of β-thalassemia-intermedia as it is a non-transfusion dependent anemia. Physicians should have high index of suspicion to diagnose malignancies in patients with β-thalassemia-intermedia.
