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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Inflammatory fibroid polyps in children: A new case report and a systematic review of the pediatric literature
Laura Righetti, Filippo Parolini, Paolo Cengia, Giovanni Boroni, Maurizio Cheli, Aurelio Sonzogni, Daniele Alberti
Laura Righetti, Filippo Parolini, Giovanni Boroni, Department of Pediatric Surgery, Spedali Civili Hospital, 25123 Brescia, Italy
Paolo Cengia, Department of Surgery, Spedali Civili Hospital, 25123 Brescia, Italy
Maurizio Cheli, Department of Pediatric Surgery, Papa Giovanni XXXIII Hospital, 24127 Bergamo, Italy
Aurelio Sonzogni, Department of Pathology, Papa Giovanni XXXIII Hospital, 24127 Bergamo, Italy
Daniele Alberti, Department of Pediatric Surgery, Spedali Civili Hospital, University of Brescia, 25123 Brescia, Italy
Author contributions: Righetti L, Parolini F, Cengia P and Boroni G conceptualized and designed the study, designed the data collection instruments, drafted the initial manuscript, reviewed and revised the manuscript; Cheli M, Sonzogni A and Alberti D conceptualized the study and critically reviewed the manuscript; all the authors approved the final manuscript as submitted.
Conflict-of-interest statement: We hereby declare that the following information relevant to this article are true to the best of our knowledge: The above mentioned manuscript has not been published, accepted for publication or under editorial review for publication elsewhere and it won’t be submitted to any other journal while under consideration for publication in your Journal; we have no financial relationship relevant to this article to disclose; there isn’t any conflict of interest relevant to this article; all authors participated in the concept and design, analysis and interpretation of data, drafting and revising the manuscript, and they have approved the manuscript as submitted.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Filippo Parolini, BS, MD, Department of Paediatric Surgery, Spedali Civili Hospital, Piazzale Spedali Civili 1, 25123 Brescia, Italy. parfil@hotmail.it
Telephone: +39-3-3996201 Fax: +39-3-3996154
Received: July 14, 2015
Peer-review started: July 15, 2015
First decision: July 31, 2015
Revised: September 12, 2015
Accepted: September 29, 2015
Article in press: September 30, 2015
Published online: November 8, 2015
Processing time: 118 Days and 22.1 Hours
AIM: To study that inflammatory fibroid polyps (IFPs) in children are extremely uncommon tumors that may occur throughout the gastrointestinal tract.
METHODS: A systematic review of the pediatric literature and a report of a new case of IFP is also presented. The PubMed database was searched for original studies on pediatric IFPs since 1960, according to “Preferred reporting items for systematic reviews and meta-analyses” guidelines for systematic reviews.
RESULTS: Five studies were finally enclosed, encompassing 6 children with IFPs (mean age 64 mo). Tumors were located in the stomach (2 patients), in the small bowel (2 patients), in the rectum (1 patient) and in the colon (1 patient). Open surgery was performed in all patients and complete excision of the mass was achieved in all cases. All patients are alive and free of symptom. Authors described a further case of a 3-year-old boy with a large duodenal IFP, in whom the tumor was removed by “en block resection”. The presence of IFP throughout the gastrointestinal tract and its variable clinical appearances make it difficult to diagnose. An accurate pre-operative assessment is fundamental in order to differentiate IFP from other more aggressive gastrointestinal tumor, enabling unnecessary demolitive surgery.
CONCLUSION: When complete resection of the IFP is achieved, the prognosis is excellent.
Core tip: We present a new case of inflammatory fibroid polyp (IFP) occurring in a 3-year-old child who, to the best of our knowledge, is the first reported case of duodenal IFP in childhood. Below is a detailed systematic review of the literature on paediatric IFPs, focusing on etiopatogenesis, clinical presentation, diagnostic assessment and treatment.
