Özdemir Ö, Kasımoğlu G, Bak A, Sütlüoğlu H, Savaşan S. Mast cell activation syndrome: An up-to-date review of literature. World J Clin Pediatr 2024; 13(2): 92813 [PMID: 38948000 DOI: 10.5409/wjcp.v13.i2.92813]
Corresponding Author of This Article
Öner Özdemir, MD, Professor, Department of Pediatric Allergy and Immunology, Sakarya University, Adnan Menderes cad, Sakarya, Adapazarı 54100, Türkiye. ozdemir_oner@hotmail.com
Research Domain of This Article
Allergy
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Pediatr. Jun 9, 2024; 13(2): 92813 Published online Jun 9, 2024. doi: 10.5409/wjcp.v13.i2.92813
Mast cell activation syndrome: An up-to-date review of literature
Öner Özdemir, Gökçe Kasımoğlu, Ayşegül Bak, Hüseyin Sütlüoğlu, Süreyya Savaşan
Öner Özdemir, Department of Pediatric Allergy and Immunology, Sakarya University, Sakarya, Adapazarı 54100, Türkiye
Gökçe Kasımoğlu, Ayşegül Bak, Department of Pediatrics, Sakarya University, Sakarya, Adapazarı 54100, Türkiye
Hüseyin Sütlüoğlu, Department of Pediatrics, Kocaeli City Hospital, Kocaeli 50123, Türkiye
Süreyya Savaşan, Department of Pediatrics, Children’s Hospital of Michigan, Hematology/Oncology, Central Michigan University College of Medicine, Mount Pleasant, MI 48859, United States
Süreyya Savaşan, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 12345, United States
Author contributions: Özdemir Ö, Kasımoğlu G, Bak A design, conceptualization, methodology; Kasımoğlu G, Bak A data curation, research, writing-original draft preparation; Sütlüoğlu H, Savaşan S analysis and investigation; Özdemir Ö, Savaşan S supervision; Sütlüoğlu H software, validation; all authors writing-reviewing and editing.
Conflict-of-interest statement: The authors whose names are listed above, certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or non-financial interest in the subject matter or materials discussed in this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Öner Özdemir, MD, Professor, Department of Pediatric Allergy and Immunology, Sakarya University, Adnan Menderes cad, Sakarya, Adapazarı 54100, Türkiye. ozdemir_oner@hotmail.com
Received: February 6, 2024 Revised: May 3, 2024 Accepted: May 28, 2024 Published online: June 9, 2024 Processing time: 122 Days and 1.9 Hours
Abstract
Mast cells are a subtype of white blood cells and are involved in the immune system. These cells contain many chemical substances called mediators, which are involved in the allergic response. The fact that mast cells play a role in many events that require urgent intervention, especially anaphylaxis, has led to a more detailed study of these cells. The diseases also caused by dysfunctions of mast cells have been examined in many circumstances. For instance, mast cell activation syndrome is known as an augmented number of cells due to decreased cell death, resulting in clinical symptoms affecting many systems. The main common symptoms include flushing, hypotension, urticaria, angioedema, headache, vomiting and diarrhea. Although the underlying mechanism is not yet clearly known, we aim to review the literature in a broad perspective and bring together the existing knowledge in the light of the literature due to the diversity of its involvement in the body and the fact that it is a little known syndrome.
Core Tip: Mast cell activation syndrome is a rare disease that is mostly diagnosed based on clinical symptoms. It is a disorder that should be considered with specific signs and symptoms of mast cell activation in individuals with skin, gastrointestinal, cardiovascular, respiratory, and neurological system involvement.
