Taherkhani R, Farshadpour F. Pediatric case with vaccine-related poliovirus infection: A case report. World J Clin Pediatr 2021; 10(5): 106-111 [PMID: 34616652 DOI: 10.5409/wjcp.v10.i5.106]
Corresponding Author of This Article
Fatemeh Farshadpour, PhD, Associate Professor, Department of Virology, School of Medicine, Bushehr University of Medical Sciences, Moallem Street, Bushehr 7514633341, Iran. f.farshadpour@bpums.ac.ir
Research Domain of This Article
Virology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Pediatr. Sep 9, 2021; 10(5): 106-111 Published online Sep 9, 2021. doi: 10.5409/wjcp.v10.i5.106
Pediatric case with vaccine-related poliovirus infection: A case report
Reza Taherkhani, Fatemeh Farshadpour
Reza Taherkhani, Fatemeh Farshadpour, Department of Virology, School of Medicine, Bushehr University of Medical Sciences, Bushehr 7514633341, Iran
Author contributions: Farshadpour F and Taherkhani R designed and performed the study; Farshadpour F drafted and edited the manuscript; all authors approved the final draft of the manuscript.
Supported byDeputy Research and Affairs of Bushehr University of Medical Sciences, Bushehr, Iran, No. 4359.
Informed consent statement: Written informed consent was obtained from the patient’s legal guardian for publication of this case report.
Conflict-of-interest statement: The authors of this paper declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fatemeh Farshadpour, PhD, Associate Professor, Department of Virology, School of Medicine, Bushehr University of Medical Sciences, Moallem Street, Bushehr 7514633341, Iran. f.farshadpour@bpums.ac.ir
Received: March 24, 2021 Peer-review started: March 24, 2021 First decision: April 29, 2021 Revised: April 29, 2021 Accepted: July 2, 2021 Article in press: July 2, 2021 Published online: September 9, 2021 Processing time: 165 Days and 8.9 Hours
Abstract
BACKGROUND
As long as oral poliovirus vaccine (OPV) is used, the potential risk for the emergence of vaccine-related polioviruses remains.
CASE SUMMARY
We report a case of Sabin-like type 1 poliovirus infection in an immunocompetent 17-mo-old child after receiving four scheduled doses of OPV. Somehow, the four doses did not confer full protection, possibly because of interference created by other enteroviruses.
CONCLUSION
The surveillance of vaccine-related polioviruses has important implications for improving health policies and vaccination strategies. Missed cases of vaccine-related poliovirus infection might pose a potential risk to global poliovirus eradication. Therefore, the global withdrawal of OPV and a shift to the inclusion of only inactivated poliovirus vaccine in the vaccination schedule is the main objective of the polio eradication program.
Core Tip: In this study, we report an unusual case of Sabin-like type 1 poliovirus infection in an immunocompetent 17-mo-old child after receiving four scheduled doses of oral poliovirus vaccine (OPV). Somehow, the four doses did not confer full protection, which may have been caused by interference created by the other enteroviruses. The surveillance of vaccine-related polioviruses (VRPVs) has important implications for improving health policies and vaccination strategies. Missed cases of VRPV infection might pose a potential risk to global poliovirus eradication. Therefore, the global withdrawal of OPV and a shift to including only inactivated poliovirus vaccine in the vaccination schedule is the main objective of the polio eradication program.
