Unraveling the role of epidermal growth factor receptor in oral lesions: Key to non surgical treatment modes

Figure 1 Epidermal growth factor receptor structure: Extracellular domain, transmembrane pass, intracellular domain, ligand binding, cysteine-rich domains. Intracellular domain includes the kinase domain and cytoplasmic tail. EGFR: Epidermal growth factor receptor; ECD: Extracellular domain; TM: Transmembrane pass; ICD: Intracellular domain; ARGN: Amphiregulin; EPGN: Epiregulin; TGF-α: Transforming growth factor alpha; TK: Tyrosine kinase; NRG: Neuregulin.

Figure 2 Epidermal growth factor receptor and its major ligands epidermal growth factor, transforming growth factor alpha, neuregulin, amphiregulin and epiregulin. ECD: Extracellular domain; TM: Transmembrane pass; ICD: Intracellular domain; LB: Ligand binding; CR: Cysteine-rich; KD: Kinase domain; CT: Cytoplasmic tail.