Minireviews
Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Stomatol. May 20, 2014; 3(2): 19-24
Published online May 20, 2014. doi: 10.5321/wjs.v3.i2.19
Host-derived biomarkers in gingival crevicular fluid for complementary diagnosis of apical periodontitis
Mauricio Garrido, Andrea Dezerega, Alfredo Castro-Martínez, Marcela Hernández
Mauricio Garrido, Andrea Dezerega, Alfredo Castro-Martínez, Marcela Hernández, Laboratorio de Biología Periodontal, Facultad de Odontología, Universidad de Chile, Santiago 8380492, Chile
Mauricio Garrido, Andrea Dezerega, Departamento de Odontología Conservadora, Facultad de Odontología, Universidad de Chile, Santiago 8380492, Chile
Marcela Hernández, Departamento de Patología y Medicina Oral, Facultad de Odontología, Universidad de Chile, Santiago 8380492, Chile
Author contributions: All authors contributed equally to this work.
Supported by Project grants from Scientific and Technologic Investigation Resource (FONDECYT), Santiago, Chile, No. N° 1090461 and 1120138
Correspondence to: Dr. Marcela Hernández, Departamento de Patología y Medicina Oral, Facultad de Odontología, Universidad de Chile, Avenida Sergio Livingstone 943, Comuna de Independencia, Santiago 8380492, Chile. mhernandezrios@gmail.com
Telephone: +56-2-8781810 Fax: +56-2-7779724
Received: March 5, 2014
Revised: May 7, 2014
Accepted: May 14, 2014
Published online: May 20, 2014
Processing time: 75 Days and 12.7 Hours
Core Tip

Core tip: The hallmark of Apical periodontitis (AP) is the development of an apical lesion of endodontic origin and can potentially lead to systemic alterations. Avoiding misdiagnosis and follow up are among the main challenges in its clinical management. The current review addresses the studies evaluating gingival crevicular fluid (GCF) composition in AP patients reported in the literature. Specific components vary in AP-affected teeth, supporting that GCF has potential for complementary diagnosis and treatment follow-up.