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World J Stomatol. Feb 20, 2014; 3(1): 1-9
Published online Feb 20, 2014. doi: 10.5321/wjs.v3.i1.1
Relationship between periodontitis and cardiovascular diseases: A literature review
Alper Kizildag, Taner Arabaci, Gulnihal Emrem Dogan
Alper Kizildag, Taner Arabaci, Gulnihal Emrem Dogan, Department of Periodontology, Faculty of Dentistry, Ataturk University, 25240 Erzurum, Turkey
Author contributions: Kizildag A, Arabaci T and Emrem Dogan G contributed equally to this work; Kizildag A analyzed the literature and wrote the paper, Arabaci T and Emrem Dogan G designed and prepared the paper.
Correspondence to: Taner Arabaci, DDS, PhD, Department of Periodontology, Faculty of Dentistry, Ataturk University, Atalar Mah., Yuzuncuyil Street, Yakutiye, 25240 Erzurum, Turkey. t-arabaci@hotmail.com
Telephone: +90-442-2311731 Fax: +90-442-2360945
Received: June 29, 2013
Revised: November 11, 2013
Accepted: November 15, 2013
Published online: February 20, 2014
Processing time: 235 Days and 18.6 Hours
Abstract

Periodontitis and cardiovascular disease have a complex etiology and genetics and share some common risk factors (i.e., smoking, age, diabetes, etc.). In recent years, the relationship between periodontal disease and cardiovascular disease has been investigated extensively. This research mostly focused on the fact that periodontitis is an independent risk factor for cardiovascular disease. Our aim in this article is to investigate the etiological relationship between periodontal disease and cardiovascular disease and the mechanisms involved in this association. According to the current literature, it is concluded that there is a strong relationship between these chronic disorders.

Keywords: Periodontitis; Cardiovascular disease; Etiological factors; Serum lipids; Chronic inflammation

Core tip: In recent decades, researchers have investigated the relationship between cardiovascular and periodontal disease because they have same risk factors. As a result of this research, a relationship between periodontitis and cardiovascular disease has been found. Inflammation markers, heat shock protein and serum lipid levels have been found to be higher in patients with periodontal and cardiovascular disease. Therefore, we investigated previous publications and aim to add a new point of view to the literature.