Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Respirol. Jul 28, 2015; 5(2): 65-68
Published online Jul 28, 2015. doi: 10.5320/wjr.v5.i2.65
Published online Jul 28, 2015. doi: 10.5320/wjr.v5.i2.65
Causes of failure in acute respiratory distress syndrome modeling and treatment in animal research and new approaches
Emine Yilmaz Sipahi, Department of Medical Pharmacology, Faculty of Medicine, Bulent Ecevit University, Kozlu, 67600 Zonguldak, Turkey
Author contributions: Yilmaz Sipahi E solely contributed to this paper.
Conflict-of-interest statement: The author has no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Emine Yilmaz Sipahi, MD, Professor, Department of Medical Pharmacology, Faculty of Medicine, Bulent Ecevit University, Kozlu, 67600 Zonguldak, Turkey. dresipahi@yahoo.com
Telephone: +90-372-2613212 Fax: +90-372-2612064
Received: January 27, 2015
Peer-review started: January 27, 2015
First decision: March 6, 2015
Revised: April 13, 2015
Accepted: May 26, 2015
Article in press: May 27, 2015
Published online: July 28, 2015
Peer-review started: January 27, 2015
First decision: March 6, 2015
Revised: April 13, 2015
Accepted: May 26, 2015
Article in press: May 27, 2015
Published online: July 28, 2015
Core Tip
Core tip: Acute respiratory distress syndrome (ARDS) is a syndrome with multiple risk factors that trigger the acute onset of respiratory insufficiency. ARDS is still one of the most fatal diseases with a high mortality rate in intensive care units. Mortality rates remain unchanged, pharmacotherapies have a very limited role in the management of ARDS and additional treatments are sorely needed. Animal models provide a bridge between patients and the laboratory bench, but these models have certain limitations and to date, no single animal model reproduces all the characteristics of human ARDS. Despite these limitations, the complex pathogenesis of ARDS makes animal models necessary.