Palkar AV, Agrawal A, Verma S, Iftikhar A, Miller EJ, Talwar A. Post splenectomy related pulmonary hypertension. World J Respirol 2015; 5(2): 69-77 [PMID: 26949600 DOI: 10.5320/wjr.v5.i2.69]
Corresponding Author of This Article
Arunabh Talwar, MD, FCCP, Department of Pulmonary, Critical Care and Sleep Medicine, North Shore - LIJ Health System, 410 Lakeville Rd. Suite 107 New Hyde Park, New York, NY 11040, United States. arunabhtalwar1@gmail.com
Research Domain of This Article
Respiratory System
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Respirol. Jul 28, 2015; 5(2): 69-77 Published online Jul 28, 2015. doi: 10.5320/wjr.v5.i2.69
Post splenectomy related pulmonary hypertension
Atul V Palkar, Abhinav Agrawal, Sameer Verma, Asma Iftikhar, Edmund J Miller, Arunabh Talwar
Atul V Palkar, Sameer Verma, Asma Iftikhar, Edmund J Miller, Arunabh Talwar, Department of Pulmonary, Critical Care and Sleep Medicine, North Shore - LIJ Health System, New York, NY 11040, United States\
Abhinav Agrawal, Department of Medicine, Monmouth Medical Center, Long Branch, NJ 07740, United States
Sameer Verma, Asma Iftikhar, Edmund J Miller, Arunabh Talwar, Feinstein Institute of Medical Research, Center for Heart and Lung Research, New York, NY 11030, United States
Author contributions: All the authors equally contributed to this work.
Supported by NIH 1R01HL111469 and ECRIP Fellowship.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Arunabh Talwar, MD, FCCP, Department of Pulmonary, Critical Care and Sleep Medicine, North Shore - LIJ Health System, 410 Lakeville Rd. Suite 107 New Hyde Park, New York, NY 11040, United States. arunabhtalwar1@gmail.com
Telephone: +1-516-4655400 Fax: +1-516-4655454
Received: January 29, 2015 Peer-review started: January 30, 2015 First decision: March 6, 2015 Revised: March 25, 2015 Accepted: May 8, 2015 Article in press: May 11, 2015 Published online: July 28, 2015 Processing time: 186 Days and 13.4 Hours
Abstract
Splenectomy predisposes patients to a slew of infectious and non-infectious complications including pulmonary vascular disease. Patients are at increased risk for venous thromboembolic events due to various mechanisms that may lead to chronic thromboembolic pulmonary hypertension (CTEPH). The development of CTEPH and pulmonary vasculopathy after splenectomy involves complex pathophysiologic mechanisms, some of which remain unclear. This review attempts to congregate the current evidence behind our understanding about the etio-pathogenesis of pulmonary vascular disease related to splenectomy and highlight the controversies that surround its management.
Core tip: Pulmonary hypertension is an often under-recognized non-infectious complication after splenectomy. The mechanisms for the development of pulmonary hypertension in this setting are multifactorial and are not clearly elucidated. We attempt to outline and highlight the current evidence behind these proposed mechanisms of post splenectomy related pulmonary hypertension.
